Elevations of inflammatory and procoagulant biomarkers in elderly persons with renal insufficiency
Elevations of inflammatory and procoagulant biomarkers in elderly persons with renal insufficiency
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DOI：
10.1161/01.cir.0000042700.48769.59
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发表时间：
2003-01-07
期刊：
影响因子：
37.8
通讯作者：
Psaty, BM
中科院分区：
文献类型：
--
作者：
Shlipak, MG;Fried, LF;Psaty, BM
背景-在一些前瞻性研究中，肾功能不全与心血管疾病事件和死亡率有关，但风险升高的机制尚不清楚。肾功能不全与炎症和促凝血标志物之间的联系知之甚少，而炎症和促凝血标志物是肾脏疾病心血管风险的潜在介体。方法和结果-使用心血管健康研究的基线数据来评估肾功能不全与8种炎症和促凝血因素的横断面相关性。心血管健康研究是一项基于人群的队列研究，涉及5888名年龄大于或等于65岁的受试者。C反应蛋白。纤维蛋白原、第VIII因子和第VIIIc因子水平在几乎所有参与者中都被珍视；白细胞介素6、细胞间黏附分子-1、纤溶酶-抗纤溶酶复合体和D-抖动在近一半参与者中被检测到。肾功能不全的定义是，女性的血清肌酐水平大于或等于1.3 mg/dL，男性大于或等于1.5 mg/dL。在对其他基线特征进行调整后，采用多元线性回归方法比较肾功能不全患者和非肾功能不全患者各生物标记物的调整后平均水平。心血管健康研究参与者中有617人(11%)存在肾功能不全。调整基线差异后，肾功能不全患者的C-反应蛋白、纤维蛋白原、白介素6、第VIII因子、第VIIIc因子、纤溶酶-抗纤溶酶复合体和D-dieter水平显著升高(P
Background-Renal insufficiency has been associated with cardiovascular disease events and mortality in several prospective studies, but the mechanisms for the elevated risk are not clear. Little is known about the association of renal insufficiency with inflammatory and procoagulant markers, which are potential mediators for the cardiovascular risk of kidney disease.Methods and Results-The cross-sectional association of renal insufficiency with 8 inflammatory and procoagulant factors was evaluated using baseline data from the Cardiovascular Health Study, a population-based cohort study of 5888 subjects aged greater than or equal to65 years. C-reactive protein. fibrinogen, factor VIII, and factor VIIIc levels were treasured in nearly all participants; interleukin-6, intercellular adhesion molecule-1, plasmin-antiplasmin complex, and D-dither levels were measured in nearly half of participants. Renal insufficiency was defined as a serum creatinine level greater than or equal to1.3 mg/dL in women and greater than or equal to1.5 mg/dL in men. Multivariate linear regression was used to compare adjusted mean levels of each biomarker in persons with and without renal insufficiency after adjustment for other baseline characteristics. Renal insufficiency was present in 617 (11%) of Cardiovascular Health Study participants. After adjustment for baseline differences, levels of C-reactive protein, fibrinogen, interleukin-6, factor VIII, factor VIIIc, plasmin-antiplasmin complex, and D-dieter were significantly greater among persons with renal insufficiency (P