Overdose and risk factors for coronavirus disease 2019
Overdose and risk factors for coronavirus disease 2019
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DOI：
10.1016/j.drugalcdep.2020.108047
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发表时间：
2020-07-01
影响因子：
4.2
通讯作者：
Desai, Roshni
中科院分区：
文献类型：
--
作者：
Slaunwhite, Amanda Kathleen;Gan, Wen Qi;Desai, Roshni
背景：加拿大不列颠哥伦比亚省(卑诗省)发生冠状病毒病2019年(新冠肺炎)和服药过量(BC)两起突发公共卫生事件，应对工作力度重大。本研究旨在量化2015-2017年间非致命性服药过量人群与非服药过量人群中新冠肺炎致死相关已知危险因素的患病率。方法：数据来自卑诗省服药过量队列，包括20%随机抽样的卑诗省居民和2015年1月至2017年12月在卑诗省服药非致命性过量服药者。用卡方检验和Logistic回归分析比较服药过量史的危险因素。结果：与既往没有发生过非致命性服药过量事件的人相比，有非致命性服药过量史的人发生与新冠肺炎严重疾病相关的4种已知慢性病中的3种(慢性肺病、糖尿病、冠心病)的可能性显著高于无服药过量史者。结论：服药过量者更有可能出现多种与因新冠肺炎发生严重疾病相关的慢性病。出现这些危险因素的可能性增加，反映了有服药过量史的人所经历的社会和健康不平等。
Background: There have been significant efforts to respond to the two public health emergencies of coronavirus disease 2019 (COVID-19) and overdose in British Columbia (BC), Canada. The purpose of this study was to quantify the prevalence of known risk factors associated with mortality due to COVID-19 for persons who have had a non-fatal overdose during 2015-2017 in comparison to persons who have not had an overdose.Methods: Data were extracted from the BC Provincial Overdose Cohort which includes a 20 % random sample of BC residents and persons who have had a non-fatal overdose in BC from January 2015 to December 2017. Chi-square tests and logistic regression were used to compare risk factors by overdose history.Results: Persons who had a non-fatal overdose were significantly more likely to have three (chronic pulmonary disease, diabetes, coronary heart disease) of the four known chronic conditions associated with the development of severe illness due to COVID-19 compared to persons who did not have a previous non-fatal overdose event.Conclusion: Persons who had an overdose were more likely to have several chronic conditions associated with the development of severe illness due to COVID-19. The increased likelihood of having these risk factors is reflective of the social and health inequities experienced by persons who have a history of overdose.