Ring-fused hexahydro-1,2,4,5-tetrazines: synthesis, structure, and mechanistic studies on isolable rotational isomers
Ring-fused hexahydro-1,2,4,5-tetrazines: synthesis, structure, and mechanistic studies on isolable rotational isomers
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DOI：
10.1039/d2cc06170h
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发表时间：
2022-12-12
影响因子：
4.9
通讯作者：
Suga，Hiroyuki
中科院分区：
文献类型：
--
作者：
Toda，Yasunori;Kooguchi，Airi;Suga，Hiroyuki
我们设计了六氢-1，2，4，5-四氮杂环上C(Sp2)-C(Sp3)轴上构象稳定的旋转异构体。利用硅胶柱层析在室温下成功分离了各旋转体。核磁共振动力学研究证实了该异构体的异构化反应机理。
We designed conformationally stable rotational isomers around the C(sp2)–C(sp3) axis at the C3-position of hexahydro-1,2,4,5-tetrazines. Isolation of each rotamer by silica gel column chromatography was successfully achieved at room temperature. The proposed isomerization mechanism of the rotamers was supported by NMR kinetic studies.