Biodegradability of poly(lactic-co-glycolic acid) and poly(L-lactic acid) after deep-ultraviolet femtosecond and nanosecond laser irradiation
Biodegradability of poly(lactic-co-glycolic acid) and poly(L-lactic acid) after deep-ultraviolet femtosecond and nanosecond laser irradiation
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DOI：
10.1007/s00339-017-1055-6
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发表时间：
2017-06-01
影响因子：
2.7
通讯作者：
Terakawa, Mitsuhiro
中科院分区：
文献类型：
--
作者：
Shibata, Akimichi;Machida, Manan;Terakawa, Mitsuhiro
在本研究中，我们研究了不同脉冲持续时间的深紫外激光照射下可生物降解聚合物薄膜的生物降解性的变化。吸水率和质量变化的测量以及显微镜观察表明，飞秒激光照射显着加速了可生物降解聚合物薄膜的降解速率，而纳秒激光照射没有引起可比程度的变化。 X射线光电子能谱和X射线衍射分析表明，PLGA等非晶态聚合物在不同脉冲持续时间的激光照射下生物降解性的差异归因于化学结构的差异，而PLLA等结晶性聚合物的化学结构和结晶度的差异影响着PLLA等结晶性聚合物的生物降解性。获得的结果表明，深紫外激光加工能够制造具有理想降解率的组织支架。
In this study, we investigated the change in biodegradability of biodegradable polymer films by deep-ultraviolet laser irradiation with different pulse durations. Measurements of water absorption and mass change as well as microscopic observation revealed that the femtosecond laser irradiation significantly accelerated the degradation rate of the biodegradable polymer films, whereas the nanosecond laser irradiation did not induce a comparable degree of change. Analyses with X-ray photoelectron spectroscopy and X-ray diffraction indicate that the difference in the biodegradability following laser irradiation with different pulse durations is attributable to the difference in chemical structure for amorphous polymers including PLGA, while the difference in chemical structure as well as crystallinity affects the biodegradability for crystalline polymer including PLLA. The obtained results suggest that deep-ultraviolet laser processing enables the fabrication of a tissue scaffold with a desirable degradation rate.