Varicella-zoster virus load and cochleovestibular symptoms in Ramsay Hunt syndrome
Varicella-zoster virus load and cochleovestibular symptoms in Ramsay Hunt syndrome
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DOI：
10.1177/000348940611500312
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发表时间：
2006-03-01
影响因子：
1.4
通讯作者：
Fukuda, S
中科院分区：
文献类型：
--
作者：
Ohtani, F;Furuta, Y;Fukuda, S
目的：水痘-带状疱疹病毒(VZV)重新激活导致Ramsay Hunt综合征(RHS)患者出现耳蜗前庭症状(CVSS)的机制尚不清楚。本研究分析了VZV负荷与RHS患者CVSS发病的关系。方法：RHS患者56例，合并CVSS者29例(FP组)，无CVSS者27例(组2)。用定量聚合酶链式反应检测唾液中VZV DNA拷贝数。抗VZV抗体检测采用双抗体夹心法。结果：两组间病毒最大拷贝数差异无统计学意义。在第1组，CVSS发生在VZV复活的早期和消退期之间的不同时间。部分患者CVSS发生在VZV再激活的早期，在带状疱疹和FP发生之前。结论：VZV再激活后的神经炎或迷路炎的进展导致第八颅神经功能障碍的发展有多种不同的模式。我们的数据提示，RHS中的CVSS也可能是由螺旋神经节和/或前庭神经节中VZV的重新激活引起的。
Objectives: The mechanism by which varicella-zoster virus (VZV) reactivation causes cochleovestibular symptoms (CVSs) in patients with Ramsay Hunt syndrome (RHS) remains to be elucidated. The present study analyzed the relationship between VZV load and the onset of CVSs in RHS.Methods: The subjects consisted of 56 patients with RHS; 29 exhibited CVSs and facial paralysis (FP; group 1), and 27 exhibited FP without CVSs (group 2). The VZV DNA copy number in the saliva was measured with a quantitative polymerase chain reaction. Anti-VZV antibodies were assayed by an enzyme-linked immunosorbent assay with paired sera.Results: There was no significant difference in maximum viral copy number between the two groups. In group 1, CVSs occurred at various times between the early phase and the regression phase of VZV reactivation. In some patients, CVSs occurred in the early phase of VZV reactivation, before the onset of zoster lesions and FP.Conclusions: There are various different patterns in the development of eighth cranial nerve dysfunction, which is caused by progression of neuritis or labyrinthitis following VZV reactivation. Our data suggest that CVSs in RHS may also be caused by reactivation of VZV in the spiral and/or vestibular ganglia.