Assessment of COVID-19 as the Underlying Cause of Death Among Children and Young People Aged 0 to 19 Years in the US.
Assessment of COVID-19 as the Underlying Cause of Death Among Children and Young People Aged 0 to 19 Years in the US.
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对 COVID-19 作为美国 0 至 19 岁儿童和青少年根本死因的评估。
DOI：
10.1001/jamanetworkopen.2022.53590
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发表时间：
2023-01-03
影响因子：
13.8
通讯作者：
Ratmann, Oliver
中科院分区：
文献类型：
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作者：
Flaxman, Seth;Whittaker, Charles;Semenova, Elizaveta;Rashid, Theo;Parks, Robbie M.;Blenkinsop, Alexandra;Unwin, H. Juliette T.;Mishra, Swapnil;Bhatt, Samir;Gurdasani, Deepti;Ratmann, Oliver
2019冠状病毒病在美国0至19岁儿童和青少年死亡的潜在原因中排名第几？在美国0至19岁的儿童和青少年中，COVID-19在所有死亡原因中排名第八，在疾病相关死亡原因中排名第五（不包括意外伤害、袭击和自杀），在传染病或呼吸道疾病导致的死亡中排名第一。COVID-19死亡人数占该年龄组所有死亡原因的2%。在这项研究中，COVID-19给儿童和年轻人带来了巨大的疾病负担，因此药物和非药物干预对于限制病毒传播和减轻严重疾病仍然很重要。这项横断面研究评估了COVID-19是否是美国0至19岁儿童和青少年死亡的十大原因之一。COVID-19是美国超过94万人死亡的根本原因，包括至少1289名0至19岁的儿童和青少年，其中至少821人在2021年8月1日至2022年7月31日的1年期间死亡。由于美国人的死亡率很低，因此最好在所有其他导致死亡的原因的背景下理解COVID-19在美国的死亡率负担。确定COVID-19是否是美国糖尿病死亡的主要（前10位）原因。这项2019年至2022年全国人口层面的横断面流行病学分析使用了美国疾病控制和预防中心流行病学研究广泛在线数据（WONDER）数据库中有关美国潜在死因的数据，以确定COVID-19相对于0至19岁人群其他死因的排名。2019冠状病毒病死亡人数是在2020年4月1日至2022年8月31日的12个月期间考虑的，而2019年、2020年和2021年的主要非2019冠状病毒病死亡人数则是在2020年4月1日至2022年8月31日的12个月期间考虑的。根据死亡总数、每10万人口的粗死亡率和所有死亡原因的百分比，使用国家卫生统计中心113个选定的死亡原因，按年龄组（<1岁，1-4岁，5-9岁，10- 1-4岁，15-19岁）对0至19岁的死亡原因进行排名。在研究期间，0至19岁的个人中有821例COVID-19死亡，导致总体粗死亡率为每10万人1.0人; 1岁以下的人为每10万人4.3人; 1至4岁的人为每10万人0.6人; 5至9岁每10万人中有0.4人; 10至14岁每10万人中有0.5人; 15至19岁每10万人中有1.8人。2021年8月1日至2022年7月31日期间，COVID-19死亡率是美国0至19岁人群的十大死亡原因之一，在所有死亡原因中排名第八，在疾病相关死亡原因中排名第五（不包括意外伤害、袭击和自杀），与2019年相比，传染病或呼吸道疾病导致的死亡人数居首位。COVID-19死亡人数占该年龄组所有死亡原因的2%。这项研究的结果表明，COVID-19是导致死亡的主要原因。它每年造成的死亡人数远远超过疫苗问世前一段时期历史上任何疫苗可预防的疾病。各种因素，包括漏报和未考虑COVID-19作为其他疾病死亡原因的作用，意味着这些估计可能低估了COVID-19的真实死亡率负担。这项研究的结果强调了COVID-19与艾滋病的公共卫生相关性。在未来可能持续的SARS-CoV-2传播背景下，适当的药物和非药物干预（如疫苗，通风，空气清洁）将继续在限制病毒传播和减轻严重疾病中发挥重要作用。
Where does COVID-19 rank as an underlying cause of death for children and young people aged 0 to 19 years in the US? Among children and young people aged 0 to 19 years in the US, COVID-19 ranked eighth among all causes of deaths, fifth in disease-related causes of deaths (excluding unintentional injuries, assault, and suicide), and first in deaths caused by infectious or respiratory diseases. COVID-19 deaths constituted 2% of all causes of death in this age group. In this study, COVID-19 posed a significant disease burden for children and young people, so pharmaceutical and nonpharmaceutical interventions continue to be important to limit transmission of the virus and to mitigate severe disease. This cross-sectional study evaluates whether COVID-19 is among the top 10 causes of death in children and young people aged 0 to 19 years in the US. COVID-19 was the underlying cause of death for more than 940 000 individuals in the US, including at least 1289 children and young people (CYP) aged 0 to 19 years, with at least 821 CYP deaths occurring in the 1-year period from August 1, 2021, to July 31, 2022. Because deaths among US CYP are rare, the mortality burden of COVID-19 in CYP is best understood in the context of all other causes of CYP death. To determine whether COVID-19 is a leading (top 10) cause of death in CYP in the US. This national population-level cross-sectional epidemiological analysis for the years 2019 to 2022 used data from the US Centers for Disease Control and Prevention Wide-Ranging Online Data for Epidemiologic Research (WONDER) database on underlying cause of death in the US to identify the ranking of COVID-19 relative to other causes of death among individuals aged 0 to 19 years. COVID-19 deaths were considered in 12-month periods between April 1, 2020, and August 31, 2022, compared with deaths from leading non–COVID-19 causes in 2019, 2020, and 2021. Cause of death rankings by total number of deaths, crude rates per 100 000 population, and percentage of all causes of death, using the National Center for Health Statistics 113 Selected Causes of Death, for ages 0 to 19 and by age groupings (<1 year, 1-4 years, 5-9 years, 10-14 years, 15-19 years). There were 821 COVID-19 deaths among individuals aged 0 to 19 years during the study period, resulting in a crude death rate of 1.0 per 100 000 population overall; 4.3 per 100 000 for those younger than 1 year; 0.6 per 100 000 for those aged 1 to 4 years; 0.4 per 100 000 for those aged 5 to 9 years; 0.5 per 100 000 for those aged 10 to 14 years; and 1.8 per 100 000 for those aged 15 to 19 years. COVID-19 mortality in the time period of August 1, 2021, to July 31, 2022, was among the 10 leading causes of death in CYP aged 0 to 19 years in the US, ranking eighth among all causes of deaths, fifth in disease-related causes of deaths (excluding unintentional injuries, assault, and suicide), and first in deaths caused by infectious or respiratory diseases when compared with 2019. COVID-19 deaths constituted 2% of all causes of death in this age group. The findings of this study suggest that COVID-19 was a leading cause of death in CYP. It caused substantially more deaths in CYP annually than any vaccine-preventable disease historically in the recent period before vaccines became available. Various factors, including underreporting and not accounting for COVID-19’s role as a contributing cause of death from other diseases, mean that these estimates may understate the true mortality burden of COVID-19. The findings of this study underscore the public health relevance of COVID-19 to CYP. In the likely future context of sustained SARS-CoV-2 circulation, appropriate pharmaceutical and nonpharmaceutical interventions (eg, vaccines, ventilation, air cleaning) will continue to play an important role in limiting transmission of the virus and mitigating severe disease in CYP.
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DOI：
10.1016/s1473-3099(21)00475-8
发表时间：
2022-01
期刊：
The Lancet. Infectious diseases
影响因子：
--
作者：
Twohig KA;Nyberg T;Zaidi A;Thelwall S;Sinnathamby MA;Aliabadi S;Seaman SR;Harris RJ;Hope R;Lopez-Bernal J;Gallagher E;Charlett A;De Angelis D;Presanis AM;Dabrera G;COVID-19 Genomics UK (COG-UK) consortium
通讯作者：
COVID-19 Genomics UK (COG-UK) consortium
DOI：
10.1016/s0140-6736(22)00462-7
发表时间：
2022-04-02
期刊：
Lancet (London, England)
影响因子：
--
作者：
Nyberg T;Ferguson NM;Nash SG;Webster HH;Flaxman S;Andrews N;Hinsley W;Bernal JL;Kall M;Bhatt S;Blomquist P;Zaidi A;Volz E;Aziz NA;Harman K;Funk S;Abbott S;COVID-19 Genomics UK (COG-UK) consortium;Hope R;Charlett A;Chand M;Ghani AC;Seaman SR;Dabrera G;De Angelis D;Presanis AM;Thelwall S
通讯作者：
Thelwall S
DOI：
10.1093/cid/ciaa1425
发表时间：
2021-07-15
期刊：
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
影响因子：
--
作者：
Anderson EJ;Campbell JD;Creech CB;Frenck R;Kamidani S;Munoz FM;Nachman S;Spearman P
通讯作者：
Spearman P
影响因子：
8.8
作者：
Kinzina, Elvira D.;Podolskiy, Dmitriy I.;Gladyshev, Vadim N.
通讯作者：
Gladyshev, Vadim N.
影响因子：
120.7
作者：
HINMAN, AR;BRANDLINGBENNETT, AD;NIEBURG, PI
通讯作者：
NIEBURG, PI