A DNA-based system for selecting and displaying the combined result of two input variables.
A DNA-based system for selecting and displaying the combined result of two input variables.
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DOI：
10.1038/ncomms10089
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发表时间：
2015-12-08
影响因子：
16.6
通讯作者：
Gothelf KV
中科院分区：
文献类型：
--
作者：
Liu H;Wang J;Song S;Fan C;Gothelf KV
用于生物传感或生物调节的寡核苷酸技术产生大量丰富的高维信息。因此需要灵活的方法来组合不同的此类信息以形成有用的衍生输出，并立即显示这些输出。在这里，我们在基于 DNA 的系统中演示了这种功能，该系统接受两个输入数字（以 DNA 链表示），并返回它们相乘的结果，并将其作为数字写入显示中。与传统计算器不同，该系统通过从解决方案库中选择结果而不是通过逻辑运算来运行。这里演示的乘法示例说明了一种更通用的功能——为任何不同的 DNA 输入对生成唯一的输出。因此，该系统可充当查找表，并可能成为未来更强大的诊断和传感数据处理系统的关键组件。 基于 DNA 的传感器提供大量需要集成和处理的信息。在这里，作者演示了一个基于 DNA 的计算器，它接受两个输入，识别答案库中的解决方案并显示结果。
Oligonucleotide-based technologies for biosensing or bio-regulation produce huge amounts of rich high-dimensional information. There is a consequent need for flexible means to combine diverse pieces of such information to form useful derivative outputs, and to display those immediately. Here we demonstrate this capability in a DNA-based system that takes two input numbers, represented in DNA strands, and returns the result of their multiplication, writing this as a number in a display. Unlike a conventional calculator, this system operates by selecting the result from a library of solutions rather than through logic operations. The multiplicative example demonstrated here illustrates a much more general capability—to generate a unique output for any distinct pair of DNA inputs. The system thereby functions as a lookup table and could be a key component in future, more powerful data-processing systems for diagnostics and sensing. DNA based sensors provide substantial amounts of information that requires integration and processing. Here the authors demonstrate a DNA-based calculator that takes two inputs, identifies the solution in a library of answers and displays the result.