Inclusion of Strep-tag II in design of antigen receptors for T-cell immunotherapy.
Inclusion of Strep-tag II in design of antigen receptors for T-cell immunotherapy.
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DOI：
10.1038/nbt.3461
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发表时间：
2016-04
影响因子：
46.9
通讯作者：
Riddell SR
中科院分区：
文献类型：
--
作者：
Liu L;Sommermeyer D;Cabanov A;Kosasih P;Hill T;Riddell SR
The tactical introduction of Strep-tag II into synthetic antigen receptors provides engineered T cells with a marker for identification and rapid purification, and a functional element for selective antibody coated microbead-driven large-scale expansion. Such receptor designs can be applied to chimeric antigen receptors of different ligand specificities and costimulatory domains, and to T cell receptors to facilitate cGMP manufacturing of adoptive T cell therapies to treat cancer and other diseases.
