Leptin influence in craving and relapse of alcoholics and smokers.
Leptin influence in craving and relapse of alcoholics and smokers.
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DOI：
10.4021/jocmr1159w
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发表时间：
2013-06
期刊：
影响因子：
--
通讯作者：
Silva-Fonseca VA
中科院分区：
文献类型：
--
作者：
Aguiar-Nemer AS;Toffolo MC;da Silva CJ;Laranjeira R;Silva-Fonseca VA
Leptin抑制丘脑背核多巴胺信号，提示其在应激调节中的作用，并可能参与奖赏系统的神经生物学过程。本研究的目的是回顾有关瘦素对酒精和烟草渴望的影响的文献，以及是否已经有证据表明瘦素可能是指示渴望和复发风险的生物标志物。该综述使用Medline，LILACS和SciElo作为2000年至2012年期间的数据库。关键词是瘦素，物质使用障碍，渴望和戒断，在葡萄牙语和英语。只有12篇文章符合纳入标准，与酗酒者（n = 10）和吸烟者（n = 2）的渴望瘦素。在LILACS数据库中未找到研究。戒断期间瘦素水平增加，这可能与中脑边缘系统中多巴胺能作用的减少有关，导致更大强度的渴望和成瘾行为的维持。虽然很少有研究，但最近的结果表明，瘦素作为戒烟者和酗酒者复发风险的标志物是有用的。
Leptin inhibits signaling of dopamine in the nucleus accumbens, suggesting its role in regulating stress and its possible involvement in the neurobiology of reward system. The aim of this study was to review of the literature on the influence of leptin in the craving for alcohol and tobacco and whether there is already evidence that leptin may be a biomarker to indicate risk for craving and relapse. The review used as data bases Medline, LILACS and SciElo in the period between 2000 and 2012. Keywords were leptin, substance use disorders, craving and withdrawal, in Portuguese and English. Only 12 articles were met the inclusion criteria, relating leptin with craving in alcoholics (n = 10) and smokers (n = 2). No studies were found in the LILACS database. Leptin levels increase during abstinence and this may be related to a reduction of dopaminergic action in mesolimbic system, resulting in a greater intensity of craving and maintenance of addictive behavior. Although there are few studies, the most recent results indicate the usefulness of leptin as a marker of risk for relapse among smokers and alcoholics in abstinence.