Early Trends for Invasive Pneumococcal Infections in Children After the Introduction of the 13-valent Pneumococcal Conjugate Vaccine
Early Trends for Invasive Pneumococcal Infections in Children After the Introduction of the 13-valent Pneumococcal Conjugate Vaccine
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DOI：
10.1097/inf.0b013e318275614b
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发表时间：
2013-03-01
影响因子：
3.6
通讯作者：
Mason, Edward O., Jr.
中科院分区：
文献类型：
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作者：
Kaplan, Sheldon L.;Barson, William J.;Mason, Edward O., Jr.
背景资料：13价肺炎球菌结合疫苗（PCV 13）于2010年在美国被引入用于婴儿和儿童的常规接种。我们已经监测了临床和微生物学特征的侵袭性肺炎球菌感染的儿童之前和之后的PCV 13 use.Methods：婴儿和儿童照顾在8个儿童医院在美国与培养证实的侵袭性感染引起的S。在一项正在进行的前瞻性监测研究中发现了肺炎。人口统计学和临床数据记录在标准病例报告表中。结果：自2010年PCV 13常规免疫以来，侵袭性肺炎球菌感染总体下降42%，儿童下降53
Background: The 13-valent pneumococcal conjugate vaccine (PCV13) was introduced for routine administration to infants and children in 2010 in the United States. We have monitored clinical and microbiologic features of invasive pneumococcal infections among children before and after PCV13 use.Methods: Infants and children cared for at 8 children hospitals in the United States with culture-proven invasive infections caused by S. pneumoniae were identified in an ongoing prospective surveillance study. Demographic and clinical data were recorded on a standard case report form. Serotype and antimicrobial susceptibilities of isolates were determined.Results: Since routine PCV13 immunization in 2010, invasive pneumococcal infections decreased 42% overall and 53% for children