Growth hormone deficiency after treatment of acute leukaemia in children.
Growth hormone deficiency after treatment of acute leukaemia in children.
复制标题
儿童急性白血病治疗后生长激素缺乏。
DOI：
10.1136/adc.51.7.489
复制
发表时间：
1976
影响因子：
5.2
通讯作者：
D. Pearson
中科院分区：
文献类型：
--
作者：
S. Shalet;C. Beardwell;P. H. Jones;D. Pearson
研究人员对 15 名儿童在急性淋巴白血病治疗后不同时间的生长激素 (GH) 分泌情况进行了研究。 4 名儿童发现 GH 对低血糖和 Bovril 的反应均受损。其中 13 名儿童接受了预防性颅脑照射，剂量为 2500 拉德（分 10 次）或 2400 拉德（分 20 次）。与给予后一剂量的受试者相比，给予前一剂量的受试者的 GH 反应减少非常显着。然而，两组之间的其他差异包括颅脑照射后的时间长度和所使用的化疗。生长激素缺乏症的主要原因尚不清楚，但我们得出的结论是，这种情况可能发生在急性淋巴白血病成功治疗的儿童身上。
Growth hormone (GH) secretion was studied in 15 children at various times after treatment for acute lymphatic leukaemia. Impaired GH responses both to hypoglycaemia and to Bovril were found in 4 children. 13 of the children had been given prophylactic cranial irradiation of either 2500 rads in 10 fractions or 2400 rads in 20 fractions. The reduction in GH responses in those given the former dose was highly significant compared with the reduction in those given the latter dose. However, other differences between the two groups included the length of time since cranial irradiation and the chemotherapy used. The main cause of the GH deficiency is not yet clear, but we conclude that it may occur in children treated successfully for acute lymphatic leukaemia.