Plasticity in corticomotor pathways linked to a jaw protrusion training task: Potential implications for management of patients with obstructive sleep apnea.
Plasticity in corticomotor pathways linked to a jaw protrusion training task: Potential implications for management of patients with obstructive sleep apnea.
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与下巴前伸训练任务相关的皮质运动通路的可塑性：对阻塞性睡眠呼吸暂停患者管理的潜在影响。
DOI：
10.1016/j.brainres.2020.147124
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发表时间：
2020
期刊：
影响因子：
2.9
通讯作者：
Svensson P
中科院分区：
文献类型：
--
作者：
Iida T;Kothari M;Sekihata S;Shimada A;Komiyama O;Svensson P
本研究调查了重复标准化下颌前突训练 (JPT) 任务对皮质运动兴奋性的影响，并使用经颅磁刺激 (TMS) 通过咬肌和舌肌运动诱发电位 (MEP) 进行评估。 16 名健康参与者连续三天执行了三个系列的标准化 JPT 任务。参与者每天进行 41 分钟的 JPT，由三个系列组成。在所有系列中，参与者都被指示以最大下巴突出位置的 50% 和 100% 为目标。在第一个和第三个系列中没有任何反馈，但在第二个系列中，为参与者提供了定制的下颌前移装置，以帮助实现正确的前突位置。在第 1 天和第 -3 天的任务前和任务后，应用单脉冲 TMS 从右侧咬肌、右侧舌头和右侧第一背侧骨间肌 (FDI)（作为对照）引出 MEP。咬肌 MEP 和舌头 MEP 显着依赖于刺激强度 (P < 0.001) 和任务会话 (P < 0.001)。任务后第 3 天的咬肌和舌头 MEP 幅度显着高于基线值（任务前第 1 天）（P < 0.005）。 FDI MEP 仅取决于刺激强度 (P < 0.001)，而不取决于任务会话 (P = 0.677)。我们的新发现表明，执行主动且重复的 JPT 任务的参与者表现出神经可塑性，不仅咬肌而且舌肌的皮质运动兴奋性增加。这一发现可能对通过下颌前移装置治疗的阻塞性睡眠呼吸暂停患者有影响，其中下颌被动地保持在突出位置。
This study investigated the effect of a repeated and standardized jaw protrusion training (JPT) task on corticomotor excitability as assessed by motor evoked potentials (MEPs) in masseter and tongue muscle with the use of transcranial magnetic stimulation (TMS).Sixteen healthy participants performed three series of a standardized JPT task on three consecutive days. Each day participants performed 41-min of JPT consisting of three series. In all series, participants were instructed to target 50% and 100% of the maximum jaw protrusion positions. In the first and third series without any feedback but during the second series, participants were provided a custom-made mandibular advancement device to help achieve the correct protruded position. Single pulse TMS was applied to elicit MEPs from right masseter, right tongue and right first dorsal interosseous muscles (FDI) (as control), pre and post-task on Day-1 and -3.Masseter MEPs and tongue MEPs were significantly dependent on stimulus intensity (P < 0.001) and on task session (P < 0.001). Amplitude of masseter and tongue MEPs at post-task Day-3 were significantly higher compared to baseline values (pre-task Day-1) (P < 0.005). FDI MEPs were dependent on stimulus intensity only (P < 0.001) but not on task session (P = 0.677).Our novel findings suggest that participants performing an active and repeated JPT task demonstrate neuroplasticity in terms of increased corticomotor excitability not only in masseter muscles but also in tongue muscles. This finding may have implications for patients with obstructive sleep apnea treated by a mandibular advancement device where the lower jaw is passively held in a protruded position.