Heterochronic genes control the stage-specific initiation and expression of the dauer larva developmental program in Caenorhabditis elegans.
Heterochronic genes control the stage-specific initiation and expression of the dauer larva developmental program in Caenorhabditis elegans.
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DOI：
10.1101/gad.3.12b.2039
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发表时间：
1989-12
影响因子：
10.5
通讯作者：
Z. Liu;V. Ambros
中科院分区：
文献类型：
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作者：
Z. Liu;V. Ambros
我们报道了一个特定阶段的发育程序，达尔幼虫的形成，是由四个异时基因LIN-4，LIN-14，LIN-28和LIN-29在时间上调节的。这四个基因突变对达尔幼虫形成的影响表明，它们调节达尔幼虫形成的两个不同过程：(1)决定达尔幼虫开始发育的幼虫阶段；(2)达尔幼虫形态发生过程中皮下细胞的专门分化。上位性分析提出了一种模型，在该模型中，LIN-4负调控LIN-14，由此导致的LIN-14活性的时间降低指定了达尔幼虫的起始阶段。我们的结果进一步表明，达尔幼虫的皮下细胞形态发生需要LIN-28在幼虫早期阶段抑制LIN-29。
We report that a stage-specific developmental program, dauer larva formation, is temporally regulated by four heterochronic genes, lin-4, lin-14, lin-28, and lin-29. The effects of mutations in these four genes on dauer larva formation have revealed that they regulate two different processes of dauer larva formation: (1) a decision specifying the larval stage at which dauer larva development initiates, and (2) the specialized differentiation of hypodermal cells during dauer larva morphogenesis. Epistasis analysis has suggested a model in which lin-4 negatively regulates lin-14, and the resulting temporal decrease in lin-14 activity specifies the stage of dauer larva initiation. Our results further suggest that dauer larva morphogenesis by hypodermal cells requires that lin-28 acts to inhibit lin-29 during early larval stages.