Lipid rafts, ceramide and molecular transcytosis
Lipid rafts, ceramide and molecular transcytosis
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脂筏、神经酰胺和分子转胞吞作用
DOI：
10.2741/4422
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发表时间：
2016-01-01
影响因子：
3.1
通讯作者：
Jin, Si
中科院分区：
文献类型：
--
作者：
Bian, Fang;Xiong, Bin;Jin, Si
转胞吞作用是一种广泛描述的涉及各种细胞类型的顶端和基底外侧之间大分子运输的过程，对于多细胞生物在不同微环境中选择性交换物质同时维持细胞和身体稳态极其重要。不受控制的转胞吞作用涉及广泛的病理生理过程。脂筏（LR）是富含鞘脂和胆固醇的膜微结构域，能够在刺激下形成不同功能的膜宏结构域或平台。特别是，富含神经酰胺的膜微域在 LR 聚集或平台形成中发挥着极其关键的作用。值得注意的是，各种转胞吞相关分子与 LR 和神经酰胺密切相关。我们试图总结不同类型的转胞吞作用在人类健康和疾病中的作用、参与转胞吞作用的LRs的类型和功能，以及与LRs和神经酰胺相关的多种转胞吞作用相关分子的基础和高级信息。希望所有信息和讨论能够为理解 LR 与转胞吞作用的关联提供更全面的见解，并为该领域的转化意义提供一些新的启示。
Transcytosis, a widely described process concerning transport of macromolecules between the apical and basolateral sides in various cell types, is extremely important for multicellular organisms to selectively exchange materials in different microenvironments while maintaining cellular and body homeostasis. Uncontrolled transcytosis is involved in a wide range of pathophysiological processes. Lipid rafts (LRs), the sphingolipid and cholesterol-enriched membrane microdomains, enable to form different functional membrane macrodomains or platforms upon stimulations. In particular, ceramide-enriched membrane microdomains play extremely critical roles in LRs clustering or platform formations. Notably, various transcytosis-related molecules are tightly correlated with LRs and ceramide. We attempt to summarize the basic and advanced information about the roles of different types of transcytosis in human health and diseases, and the types and functions of LRs involved in transcytosis, as well as multiple transcytosis-related molecules associated with LRs and ceramide. It is hoped that all information and discussions could provide much more comprehensive insights into the understanding of the association of LRs with transcytosis, as well as shed some new light on the translational significance in this area.