Free Testosterone Level Correlated with the Metabolic Abnormalities Dependent on Central Obesity in Women with Polycystic Ovary Syndrome
Free Testosterone Level Correlated with the Metabolic Abnormalities Dependent on Central Obesity in Women with Polycystic Ovary Syndrome
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游离睾酮水平与多囊卵巢综合征女性中心性肥胖代谢异常相关
DOI：
10.1055/s-0032-1311643
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发表时间：
2012-06-01
影响因子：
1.8
通讯作者：
Yang, D.
中科院分区：
文献类型：
--
作者：
Dong, Z.;Chen, X.;Yang, D.
背景：与无多囊卵巢综合征(PCOS)的妇女相比，患有PCOS的妇女发生代谢异常的风险增加。高雄激素血症是PCOS最重要的特征之一。目的：探讨多囊卵巢综合征患者雄激素指标与代谢异常的关系。对象与方法：对408例多囊卵巢综合征患者的人体测量和生化指标进行回顾性分析。结果：多囊卵巢综合征患者代谢综合征的患病率为15.7%。总睾酮(TT)与代谢谱之间不存在关联。通过未调整的相关分析，游离睾酮(FT)与大多数代谢变量相关。与FT水平正常的女性相比，FT水平升高的女性表现出更多不利的代谢特征。经多因素Logistic回归分析调整混杂因素后，FT水平升高的女性中心性肥胖患病率高于FT水平正常的女性(优势比[OR]2.346，p=0.042)。性激素结合球蛋白水平降低的女性更有可能出现中心性肥胖、超重、空腹血糖升高、胰岛素抵抗和舒张压升高。脱氢表雄酮(DHEAS)水平升高与发生中心性肥胖(OR 0.293，p=0.001)和超重(OR 0.47，p=0.023)的几率降低有关。FT可以参与依赖于中心性肥胖的代谢紊乱的发展。提高DHEAS水平可以降低中心性肥胖和超重的风险。
Background: Women with polycystic ovary syndrome (PCOS) have increased risks of developing metabolic abnormalities compared with the women without PCOS. Hyperandrogenemia is one of the most important characteristics of PCOS. However, the correlations between hyperandrogenemia and metabolic disorders are uncertain.Aim: To elucidate the relationship between androgen indices and metabolic abnormalities in Chinese women with PCOS.Subjects and Methods: A retrospective analysis of the anthropometric and biochemical records of 408 women with PCOS.Results: The prevalence of metabolic syndrome (MetS) was 15.7% in women with PCOS. No association existed between total testosterone (TT) and metabolic profile. Free testosterone (FT) correlated with most of the metabolic variables by unadjusted correlation analyses. The women with elevated FT levels exhibited more unfavorable metabolic profiles compared with the women with normal FT levels. After adjusting for the confounding factors by multivariate logistic regression analysis, the women with elevated FT levels had higher prevalence of central obesity than the women with normal FT levels (odds ratio [OR] 2.346, p = 0.042). Women with reduced sex hormone-binding globulin levels were more likely to have central obesity, overweight, raised fasting glucose, insulin resistance, and raised diastolic blood pressure. Raised dehydroepiandrosterone sulfate (DHEAS) level was associated with a lower probability of having central obesity (OR 0.293, p = 0.001) and overweight (OR 0.47, p = 0.023).Conclusions: FT has closer association with metabolic parameters than TT. FT can involve in the development of metabolic disorders dependent on central obesity. Raised DHEAS level can reduce the risks of central obesity and overweight.