The contribution of hip geometry to the prediction of hip osteoarthritis
The contribution of hip geometry to the prediction of hip osteoarthritis
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DOI：
10.1016/j.joca.2013.06.012
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发表时间：
2013-10-01
影响因子：
7
通讯作者：
Waarsing, J. H.
中科院分区：
文献类型：
--
作者：
Castano-Betancourt, M. C.;Van Meurs, J. B. J.;Waarsing, J. H.
目的：为了确定如何以及措施的髋关节几何形状可以预测放射性事件髋关节骨关节炎（HOA）相比，众所周知的临床riskfactors.Design：研究人群是鹿特丹研究，一个前瞻性的人口为基础的队列的一部分。基线骨盆X线片用于通过两种方法测量髋关节几何形状：统计形状模型（SSM）和预定义的几何参数（PGP）。在6.5年后，对688名基线时没有放射学HOA的参与者进行了事件HOA（Kellgren和Lawrence（KL >= 2））评估。使用受试者工作特征（ROC）曲线下面积（AUC）来量化预测HOA的能力。结果：两种方法的比较表明，两者都包含其他方法无法捕获的信息。在6.5年随访时，132例髋关节发生HOA。5个PGP（Wiberg角、颈部宽度（NW）、骨盆宽度（PW）、髋轴长度（HAL）和三角指数（TI））和2个SSM（模式5和9）是HOA的显著预测因子（P = 0.007）。髋关节几何形状增加了7%的预测获得的临床风险因素（AUC = 0.67（几何形状），0.66（性别，年龄，体重指数（BMI））和合并：AUC = 0.73，分别）。模式12（与股骨头在髋臼中的位置相关）和Wiberg角是基线时无放射学体征（KL = 0）的参与者的HOA的预测因子。虽然强度的预测降低了所有变量在较长的后续行动，髋关节几何形状的贡献仍然显着（P = 0.01）。结论：髋关节几何形状有一个中等的能力来预测HOA参与者，并没有最初的迹象骨关节炎（OA），类似的，并在很大程度上独立的临床风险因素的预测值。(C)2013年国际骨关节炎研究学会。由爱思唯尔有限公司出版。保留所有权利。
Objective: To determine how well measures of hip geometry can predict radiological incident hip ostearthritis (HOA) compared to well known clinical risk factors.Design: The study population is part of the Rotterdam Study, a prospective population-based cohort. Baseline pelvic radiographs were used to measure hip geometry by two methods: Statistical Shape Models (SSM) and predefined geometry parameters (PGPs). Incident HOA (Kellgren and Lawrence (KL >= 2) was assessed in 688 participants after 6.5 years without radiographic HOA at baseline. The ability to predict HOA was quantified using the area under the Receiver Operating Characteristics (ROC) curve (AUC).Results: Comparison of the two methods showed that both contain information that is not captured by the other method. At 6.5 years follow-up 132 hips had incident HOA. Five PGPs (Wiberg angle, Neck Width (NW), Pelvic Width (PW), Hip Axis Length (HAL) and Triangular Index (TI)) and two SSM (modes 5 and 9) were significant predictors of HOA (P = 0.007). Hip geometry added 7% to the prediction obtained by clinical risk factors (AUC = 0.67 (geometry), 0.66 (gender, age, Body Mass Index (BMI)) and combining both: AUC = 0.73, respectively). Mode 12 (associated with position of the femoral head in acetabulum) and Wiberg angle were predictors of HOA in participants without radiological signs at baseline (KL = 0). Although the strength of the prediction decreased for all variables at a longer follow-up, the contribution of hip geometry was still significant (P = 0.01).Conclusions: Hip geometry has a moderate ability to predict HOA in participants with and without initial signs of osteoarthritis (OA), similar to and largely independent of the predictive value of clinical risk factors. (C) 2013 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.