Drug discovery from medicinal plants
Drug discovery from medicinal plants
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DOI：
10.1016/j.lfs.2005.09.012
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发表时间：
2005-12-22
期刊：
影响因子：
6.1
通讯作者：
Kinghorn, AD
中科院分区：
文献类型：
--
作者：
Balunas, MJ;Kinghorn, AD
目前从药用植物中发现药物的研究涉及植物学、植物化学、生物学和分子技术相结合的多方面方法。药用植物药物的发现继续提供新的和重要的线索，对各种药理学目标，包括癌症，艾滋病毒/艾滋病，阿尔茨海默氏症，疟疾和疼痛。几种植物来源的天然产物药物，包括蒿乙醚、加兰他敏、尼替西酮和噻托溴铵，最近已进入美国市场，或目前正在进行后期临床试验。作为我们的国家合作药物发现小组（NCDDG）研究项目的一部分，已从热带雨林植物物种中鉴定出许多具有潜在抗癌活性的化合物。我们的研究小组还分离出几种化合物，主要来自可食用植物物种或用作膳食补充剂的植物，它们可能起到化学预防剂的作用。虽然从药用植物中发现药物继续提供新药先导的重要来源，但遇到了许多挑战，包括植物材料的采购，适当的高通量筛选生物测定的选择和实施，以及活性化合物的放大。(c)2005年爱思唯尔公司All rights reserved.
Current research in drug discovery from medicinal plants involves a multifaceted approach combining botanical, phytochemical, biological, and molecular techniques. Medicinal plant drug discovery continues to provide new and important leads against various pharmacological targets including cancer, HIV/AIDS, Alzheimer's, malaria, and pain. Several natural product drugs of plant origin have either recently been introduced to the United States market, including arteether, galantamine, nitisinone, and tiotropium, or are currently involved in late-phase clinical trials. As part of our National Cooperative Drug Discovery Group (NCDDG) research project, numerous compounds from tropical rainforest plant species with potential anticancer activity have been identified. Our group has also isolated several compounds, mainly from edible plant species or plants used as dietary supplements, that may act as chemopreventive agents. Although drug discovery from medicinal plants continues to provide an important source of new drug leads, numerous challenges are encountered including the procurement of plant materials, the selection and implementation of appropriate high-throughput screening bioassays, and the scale-up of active compounds. (c) 2005 Elsevier Inc. All rights reserved.