Oral Squamous Cell Carcinoma: Clinicopathological Features in Patients with and without Recurrence
Oral Squamous Cell Carcinoma: Clinicopathological Features in Patients with and without Recurrence
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DOI：
10.1159/000328340
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发表时间：
2011-01-01
期刊：
影响因子：
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通讯作者：
Chaves Lourenco, Simone de Queiroz
中科院分区：
文献类型：
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作者：
Camisasca, Danielle Resende;Nunes Costa Silami, Marcos Antonio;Chaves Lourenco, Simone de Queiroz
目的：比较复发与未复发口腔鳞状细胞癌的临床病理特征。方法：确定1999年期间在一家机构接受原发性口腔鳞状细胞癌手术的所有患者的记录。收集患者的人口统计学资料、病变部位、临床和病理分期、病理分级、浸润模式、淋巴细胞浸润、神经周围浸润以及治疗和生存数据。计算每个变量的描述性统计量，并使用Kaplan-Meier和考克斯模型计算生存期。患者分为2组：复发组（n = 25）和无复发组（n = 28）。结果：舌（p = 0.02）和低分化（p = 0.04）肿瘤与复发相关。Kaplan-Meier和考克斯模型显示，吸烟和淋巴细胞浸润的缺乏与复发性口腔鳞状细胞癌的生存率最低相关。结论：肿瘤部位、吸烟和病理特征与口腔鳞癌复发有关，在口腔鳞癌治疗和随访时应考虑到这些因素。版权所有（C）2011 S. Karger AG，巴塞尔
Aim: To compare the clinicopathological profile of oral squamous cell carcinoma (OSCC) in groups with and without recurrence. Methods: Records of all patients who underwent surgery for primary OSCC at a single institution during 1999 were identified. Patient demographics, lesion site, clinical and pathologic stage, pathologic grading, pattern of invasion, lymphocytic infiltrate, perineural invasion, and treatment and survival data were collected. Descriptive statistics were calculated for each variable and survival was calculated using Kaplan-Meier and Cox models. Patients were divided into 2 groups: with (n = 25) and without (n = 28) recurrence. Results: Tongue (p = 0.02) and poorly differentiated (p = 0.04) tumors were associated with recurrence. Kaplan-Meier and Cox models revealed tobacco use and the absence of lymphocytic infiltrate to be associated with the poorest survival in recurrent OSCC. Conclusion: The tumor site, tobacco use, and pathological features were involved in the recurrence of OSCC and should be taken into account for OSCC treatment and follow-up. Copyright (C) 2011 S. Karger AG, Basel