The interplay of organ-of-Corti vibrational modes, not tectorial- membrane resonance, sets outer-hair-cell stereocilia phase to produce cochlear amplification.
The interplay of organ-of-Corti vibrational modes, not tectorial- membrane resonance, sets outer-hair-cell stereocilia phase to produce cochlear amplification.
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DOI：
10.1016/j.heares.2020.108040
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发表时间：
2020-09-15
期刊：
影响因子：
2.8
通讯作者：
Guinan JJ Jr
中科院分区：
文献类型：
--
作者：
Guinan JJ Jr
综述了偏转外毛细胞(OHC)立体纤毛的机械运动以及由此产生的OHC运动的影响，主要集中在高频耳蜗区。有人提出，覆盖膜(Tm)共振使OHC立体纤毛运动的相位适合于产生耳蜗放大，即推动基底膜(BM)的OHC力与BM速度方向相同。考虑了支持和反对TM共振假说的证据，包括使用光学相干层析成像的新的耳蜗运动测量，并得出结论，不存在这种TM共振。有证据表明，网状板(RL)径向运动的相位提前，频率比BM特征频率低约1/5个八度，这是TM和RL径向运动之间产生耳蜗放大的相位差异的主要来源。RL径向运动的相位变化似乎是由于不同的Corti器官(OOC)振动模式之间的转换，从而改变了RL相对于BM和TM运动的运动。考虑了RL径向运动相对于BM运动的大相位变化的起源和结果；这些变化的报道模式的不同可能是由于不同的视角。需要详细的运动数据和新的模型来更好地说明OOC模式的振动模式以及各种OOC结构在产生模式和模式转变中的作用。
The mechanical motions that deflect outer-hair-cell (OHC) stereocilia and the resulting effects of OHC motility are reviewed, concentrating on high-frequency cochlear regions. It has been proposed that a tectorial-membrane (TM) resonance makes the phase of OHC stereocilia motion be appropriate to produce cochlear amplification, i.e. so that the OHC force that pushes the basilar membrane (BM) is in the same direction as BM velocity. Evidence for and against the TM-resonance hypothesis are considered, including new cochlear-motion measurements using optical coherence tomography, and it is concluded that there is no such TM resonance. The evidence points to there being an advance in the phase of reticular lamina (RL) radial motion at a frequency approximately ½ octave below the BM characteristic frequency, and that this is the main source of the phase difference between the TM and RL radial motions that produces cochlear amplification. It appears that the change in phase of RL radial motion comes about because of a transition between different organ-of-Corti (OoC) vibrational modes that changes RL motion relative to BM and TM motion. The origins and consequences of the large phase change of RL radial motion relative to BM motion are considered; differences in the reported patterns of these changes may be due to different viewing angles. Detailed motion data and new models are needed to better specify the vibrational patterns of the OoC modes and the role of the various OoC structures in producing the modes and the mode transition.
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