Hydraulically-induced convective solute transport across the rabbit peritoneum.
Hydraulically-induced convective solute transport across the rabbit peritoneum.
复制标题
液压引起的对流溶质穿过兔子腹膜的输送。
DOI：
10.1038/ki.1990.162
复制
发表时间：
1990
影响因子：
19.6
通讯作者：
Henderson,LW
中科院分区：
文献类型：
--
作者：
Bell,JL;Leypoldt,JK;Frigon,RP;Henderson,LW
液压诱导对流溶质运输通过兔腹膜。腹膜透析诱导的经腹膜超滤过程中溶质的转运低于基于经腹膜溶质扩散速率的预测。以前的工作者假设，腹膜毛细血管的小动脉末端的小孔中仅发生腹膜炎诱导的对流溶质运输，而溶质扩散仅通过大的微静脉孔发生。我们通过测定液压诱导经腹膜超滤（N = 13）期间肌酐、对氨基马尿酸盐（PAH）和中性葡聚糖的筛分系数（S），在取出内脏的新西兰白色家兔中检验了该异孔性假设。一个水力引起的驱动力直接对流溶质运输通过相同的毛细孔用于扩散，因此S的所有溶质应接近统一，如果异孔隙假设是有效的。肌酐和PAH的S值分别为0.72 ± 0.03和0.67 ± 0.05，低于1，与先前在透析诱导超滤期间测定的值无差异。葡聚糖的平均S相对独立于分子大小，范围从13 μ m时的0.50到50 μ m时的0.40。因此，葡聚糖S高于先前在透析诱导超滤期间测定的那些，但仍小于1。对照实验（N = 6）表明，只有表面积，而不是运输特性的内脏被改变。这些观察结果表明，异孔性假说未能完全描述腹膜的扩散和对流传输特性。
Hydraulically-induced convective solute transport across the rabbit peritoneum. Transport of solutes during osmotically-induced transperitoneal ultrafiltration is less than would be predicted based upon rates of transperitoneal solute diffusion. Previous workers have hypothesized that osmotically-induced convective solute transport occurs only in small pores at the arteriolar end of peritoneal capillaries, whereas solute diffusion occurs only through large venular pores. We tested this heteroporosity hypothesis in the eviscerated New Zealand White rabbit by determining sieving coefficients (S) for creatinine, p-aminohippurate (PAH) and neutral dextran during hydraulically-induced transperitoneal ultrafiltration (N = 13). A hydraulically-induced driving force directs convective solute transport through the same capillary pores employed for diffusion; therefore S for all solutes should approach unity if the heteroporosity hypothesis is valid. S for creatinine and PAH were respectively 0.72 ± 0.03 and 0.67 ± 0.05, values lower than unity and not different from those previously determined during osmotically induced ultrafiltration. Mean S for dextran were relatively independent of molecular size, ranging from 0.50 at 13 Å to 0.40 at 50 Å. Thus, dextran S were higher than those previously determined during osmotically induced ultrafiltration yet still less than unity. Control experiments (N = 6) suggested that only surface area and not transport characteristics were altered by evisceration. These observations demonstrate that the heteroporosity hypothesis fails to completely describe both diffusive and convective transport properties of the peritoneum.1