RESTRICTED AND ANISOTROPIC DISPLACEMENT OF WATER IN HEALTHY CAT BRAIN AND IN STROKE STUDIED BY NMR DIFFUSION IMAGING
RESTRICTED AND ANISOTROPIC DISPLACEMENT OF WATER IN HEALTHY CAT BRAIN AND IN STROKE STUDIED BY NMR DIFFUSION IMAGING
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DOI：
10.1002/mrm.1910190223
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发表时间：
1991-06-01
影响因子：
3.3
通讯作者：
DESPRES, D
中科院分区：
文献类型：
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作者：
MOONEN, CTW;PEKAR, J;DESPRES, D
最近，水扩散被引入作为额外的MRI对比度参数（1-3）。在扩散成像方法中，在体积元素内测量随机位移。因此，扩散成像也被称为体素内非相干运动（IVIM）成像（1）。锌体内，车厢的边界，主动和被动运输，吸附到大分子，和流动都可能影响水的位移。此外，可以研究水驱替的各向异性，并且可以提供组织微观结构的额外探针（4）。莫斯利等人（5，6）报道了弥散加权MRI在卒中早期检测中的应用。这是扩散MRI的一个潜在的重要应用，因为常规MRI对于缺氧损伤具有令人不安的低对比度。莫斯利等人（5，6）表明，猫脑的区域，当受到急性中风的影响时，
Recently, water diffusion was introduced as an additional MRI contrast parameter (1-3). In diffusion imaging methods, random displacements are measured within a volume element. As a result, diffusion imaging has also been named intravoxel incoherent motion (IVIM) imaging (1). Zn vivo, boundaries of compartments, active and passive transport, adsorption to macromolecules, and flow may all influence the displacements of water. In addition, the anisotropy of the water displacement can be studied and may provide an additional probe of tissue microstructure (4). Moseley et al.(5, 6) have reported the use of diffusion-weighted MRI in the early detection of stroke. This is a potentially important application of diffusion MRI, since conventional MRI has a disappointingly low contrast for hypoxic insults. Moseley et al.(5, 6) demonstrated that regions of cat brain, when affected by acute stroke, are