Basic statistical analysis in genetic case-control studies.
Basic statistical analysis in genetic case-control studies.
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DOI：
10.1038/nprot.2010.182
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发表时间：
2011-02
期刊：
影响因子：
14.8
通讯作者：
Zondervan, Krina T.
中科院分区：
文献类型：
--
作者：
Clarke, Geraldine M.;Anderson, Carl A.;Pettersson, Fredrik H.;Cardon, Lon R.;Morris, Andrew P.;Zondervan, Krina T.
本方案描述了如何在基于人群的遗传关联病例对照研究中进行基本的统计分析。所描述的步骤涉及（i）适当选择疾病模型的关联性和相关性的测量;（ii）适当选择关联性测试;（iii）结果的可视化和解释;（iv）考虑控制多重测试的适当方法;和（v）复制策略。假设没有以前的经验与软件，如PLINK，R或Haploview，我们描述了如何使用这些流行的工具来处理单核苷酸多态性数据，以进行关联测试和可视化和解释结果。本方案假设已进行了数据质量评估和控制，如先前方案所述，因此已识别并删除了被认为可能给研究引入偏倚的样本和标记物。病例对照研究的研究设计、标记物选择和质量控制也在早期方案中进行了讨论。该方案应需要约1小时才能完成。
This protocol describes how to perform basic statistical analysis in a population-based genetic association case-control study. The steps described involve the (i) appropriate selection of measures of association and relevance of disease models; (ii) appropriate selection of tests of association; (iii) visualization and interpretation of results; (iv) consideration of appropriate methods to control for multiple testing; and (v) replication strategies. Assuming no previous experience with software such as PLINK, R or Haploview, we describe how to use these popular tools for handling single-nucleotide polymorphism data in order to carry out tests of association and visualize and interpret results. This protocol assumes that data quality assessment and control has been performed, as described in a previous protocol, so that samples and markers deemed to have the potential to introduce bias to the study have been identified and removed. Study design, marker selection and quality control of case-control studies have also been discussed in earlier protocols. The protocol should take ~1 h to complete.
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影响因子：
3.5
作者：
de Bakker, Paul I. W.;Ferreira, Manuel A. R.;Voight, Benjamin F.
通讯作者：
Voight, Benjamin F.
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y
影响因子：
2.1
作者：
Morris, Andrew P.;Zeggini, Eleftheria
通讯作者：
Zeggini, Eleftheria
影响因子：
64.8
作者：
Gibbs, RA;Belmont, JW;Tanaka, T
通讯作者：
Tanaka, T
影响因子：
9.8
作者：
Clarke, Geraldine M.;Carter, Kim W.;Cardon, Lon R.
通讯作者：
Cardon, Lon R.