Association Between Hippocampal Volume and African Neuropsychology Memory Tests in Adult Individuals with Probable Alzheimer's Disease in Democratic Republic of Congo.
Association Between Hippocampal Volume and African Neuropsychology Memory Tests in Adult Individuals with Probable Alzheimer's Disease in Democratic Republic of Congo.
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DOI：
10.3233/jad-230206
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发表时间：
2023-09
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通讯作者：
Jean Ikanga;Sabrina Hickle;Megan Schwinne;Emmanuel Epenge;Guy Gikelekele;Immaculée Kavugho;Nathan Tsengele;Mampunza Samuel;Liping Zhao;D. Qiu;Anthony Stringer;Amit M. Saindane;Alvaro Alonso;D. Drane
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作者：
Jean Ikanga;Sabrina Hickle;Megan Schwinne;Emmanuel Epenge;Guy Gikelekele;Immaculée Kavugho;Nathan Tsengele;Mampunza Samuel;Liping Zhao;D. Qiu;Anthony Stringer;Amit M. Saindane;Alvaro Alonso;D. Drane
西方研究表明，在阿尔茨海默病（AD）的发展轨迹中，海马体积和记忆之间存在潜在的关联。然而，有限的神经影像学技术和神经心理学测试适用于撒哈拉以南非洲（SSA）国家，很难建立海马和记忆在这个地方的神经解剖协会。目的本研究检测了刚果民主共和国（DRC）健康对照组（HC）和疑似AD组的海马体积和记忆。方法采用社区痴呆量表和阿尔茨海默病问卷对46例疑似AD患者和29例HC患者进行筛查。参与者在刚果民主共和国金沙萨接受神经成像，并使用非洲神经心理学电池（ANB）评估记忆。多元线性回归用于确定海马体积和记忆之间的关联。结果：疑似AD患者在ANB记忆测量中的表现明显差于HC，并且表现出更大的脑萎缩，这在内侧颞叶区域（海马，内嗅皮层）中明显明显。与国际基本患病率相比，AD和HC受试者的白色高信号发生率均较高，可能AD的患病率显著更差。两者也表现出微血管化率升高。回归分析表明，海马体积和ANB记忆测试之间的显着关联。海马萎缩可区分可能的AD和HC组。结论：本研究确立了在SSA进行神经影像学研究的可行性，证明了许多已知的神经影像学结果在可能的AD患者中使用文化上适当的记忆任务，并表明心血管问题在SSA比在西方国家更大的问题。
BACKGROUND Western studies indicate potential associations between hippocampal volume and memory in the trajectory of Alzheimer's disease (AD). However, limited availability of neuroimaging technology and neuropsychological tests appropriate for sub-Saharan African (SSA) countries makes it difficult to establish neuroanatomical associations of hippocampus and memory in this locale. OBJECTIVE This study examined hippocampal volumes and memory in healthy control (HC) and probable AD groups in the Democratic Republic of Congo (DRC). METHODS Forty-six subjects with probable AD and 29 HC subjects were screened using the Community Instrument for Dementia and the Alzheimer Questionnaire. Participants underwent neuroimaging in Kinshasa, DRC, and memory was evaluated using the African Neuropsychology Battery (ANB). Multiple linear regression was used to determine associations between hippocampal volumes and memory. RESULTS Patients with probable AD performed significantly worse than HCs on ANB memory measures, and exhibited greater cerebral atrophy, which was significantly pronounced in the medial temporal lobe region (hippocampus, entorhinal cortex). Both AD and HC subjects exhibited high rates of white matter hyperintensities compared to international base rate prevalence, which was significantly worse for probable AD. Both also exhibited elevated rates of microhemorrhages. Regression analysis demonstrated a significant association between hippocampal volume and ANB memory tests. Hippocampal atrophy discriminated probable AD from the HC group. CONCLUSIONS This study establishes the feasibility of conducting neuroimaging research in the SSA, demonstrates many known neuroimaging findings in probable AD patients hold up using culturally appropriate memory tasks, and suggest cardiovascular problems are a greater issue in SSA than in Western countries.