Evidence for a neurophysiologic auditory deficit in children with benign epilepsy with centro-temporal spikes
Evidence for a neurophysiologic auditory deficit in children with benign epilepsy with centro-temporal spikes
复制标题
DOI：
10.1007/s00702-005-0357-6
复制
发表时间：
2006-07-01
影响因子：
3.3
通讯作者：
Towell, A
中科院分区：
文献类型：
--
作者：
Liasis, A;Bamiou, DE;Towell, A
良性局灶性癫痫在儿童与中央颞峰（BECTS）是癫痫的最常见的形式之一。最近的研究对BECTS的良性本质提出了质疑，因为它们揭示了包括语言在内的许多领域的神经心理缺陷。这项研究的目的是调查夜间癫痫放电是否对听觉处理有长期影响，正如电生理测量所反映的那样，在白天，这可能会强调语言缺陷。为了解决这些问题，我们记录了12名患有BECTS的儿童以及年龄和性别匹配的对照组的基线脑电图（EEG）、睡眠脑电图和听觉事件相关电位。在BECTS患儿中，5例为单侧尖峰，3例为双侧尖峰。在睡眠期间出现单侧峰的5例患者中，与所有对照和3例双侧峰患儿的正常对称顶点分布相比，在癫痫样活动的对侧观察到听觉事件相关成分（P85-120）的不对称性。在所有患者中，与事件相关的电位分量的峰对峰幅度在统计学上都大于对照组。对减法波形（偏差-标准）的分析显示，在任何患有BECTS的儿童中没有错配负性成分的证据。我们提出，在这一组中，P85-120的异常和不匹配负性的缺失可能是对睡眠期间发生的尖峰的长期影响的反应，导致回声记忆痕迹的进化和维持中断。这些结果可能表明，患有BECTS的患者在睡眠期间在同侧半球的感觉水平上对听觉信息的处理异常。
Benign focal epilepsy in childhood with centro-temporal spikes (BECTS) is one of the most common forms of epilepsy. Recent studies have questioned the benign nature of BECTS, as they have revealed neuropsychological deficits in many domains including language. The aim of this study was to investigate whether the epileptic discharges during the night have long-term effects on auditory processing, as reflected on electrophysiological measures, during the day, which could underline the language deficits. In order to address these questions we recorded base line electroencephalograms (EEG), sleep EEG and auditory event related potentials in 12 children with BECTS and in age- and gender-matched controls. In the children with BECTS, 5 had unilateral and 3 had bilateral spikes. In the 5 patients with unilateral spikes present during sleep, an asymmetry of the auditory event related component (P85-120) was observed contralateral to the side of epileptiform activity compared to the normal symmetrical vertex distribution that was noted in all controls and in 3 the children with bilateral spikes. In all patients the peak to peak amplitude of this event related potential component was statistically greater compared to the controls. Analysis of subtraction waveforms (deviant - standard) revealed no evidence of a mismatch negativity component in any of the children with BECTS. We propose that the abnormality of P85-120 and the absence of mismatch negativity during wake recordings in this group may arise in response to the long-term effects of spikes occurring during sleep, resulting in disruption of the evolution and maintenance of echoic memory traces. These results may indicate that patients with BECTS have abnormal processing of auditory information at a sensory level ipsilateral to the hemisphere evoking spikes during sleep.