Neighborhood matters: Altered lipid metabolism in APOE4 microglia causes problems for neurons.
Neighborhood matters: Altered lipid metabolism in APOE4 microglia causes problems for neurons.
复制标题
邻近问题：APOE4 小胶质细胞脂质代谢的改变会导致神经元出现问题。
DOI：
10.1016/j.stem.2022.07.001
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发表时间：
2022
期刊：
影响因子：
23.9
通讯作者：
Jayadev,Suman
中科院分区：
文献类型：
--
作者：
Young,JessicaE;Jayadev,Suman
在本期《细胞干细胞》中，Victor等人。揭示携带阿尔茨海默病风险等位基因APOE4的人类小胶质细胞改变了脂肪代谢和细胞激活。这抑制了神经元网络的活动，强调了这些驻留在大脑中的免疫细胞的重要性，并突出了一条治疗干预的新途径。
In this issue ofCell Stem Cell, Victor et al. reveal that human microglia harboring the Alzheimer's disease risk allele APOE4 have altered lipid metabolism and cellular activation. This dampens neuronal network activity, underscoring the importance of these brain-resident immune cells and highlighting a novel pathway for therapeutic intervention.