Activated T lymphocytes disappear from circulation during endotoxemia in humans
Activated T lymphocytes disappear from circulation during endotoxemia in humans
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DOI：
10.1128/cdli.9.3.731-735.2002
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发表时间：
2002-05-01
期刊：
影响因子：
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通讯作者：
Pedersen, BK
中科院分区：
文献类型：
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作者：
Krabbe, KS;Bruunsgaard, H;Pedersen, BK
17名志愿者接受静脉注射内毒素（2 ng/kg体重）。内毒素诱导的淋巴细胞减少主要由不成熟表型(CD45RA（+) CD45RO(-)）的细胞组成，这些细胞不太可能发生凋亡（CD28(+)），而消失率最高的细胞的特征是活化表型(CD45RA（-) CD45RO(+)）以及与凋亡相关的表型(CD95（+) CD28(-)）。综上所述，内毒素诱导的淋巴细胞减少反映了活化淋巴细胞从循环中消失，容易发生凋亡。
Seventeen volunteers received an intravenous bolus of endotoxin (2 ng/kg of body weight). Endotoxin-induced lymphopenia was constituted mainly by cells with an immature phenotype (CD45RA(+) CD45RO(-)) that were less likely to undergo apoptosis (CD28(+)), whereas cells with the highest rates of disappearance were characterized by an activated phenotype (CD45RA(-) CD45RO(+)) as well as a phenotype linked to apoptosis (CD95(+) CD28(-)). In conclusion, endotoxin-induced lymphopenia reflects the disappearance from the circulation of activated lymphocytes prone to undergo apoptosis.