Evaluation method of the degree of red blood cell aggregation considering ultrasonic propagation attenuation by analyzing ultrasonic backscattering properties
Evaluation method of the degree of red blood cell aggregation considering ultrasonic propagation attenuation by analyzing ultrasonic backscattering properties
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DOI：
10.1007/s10396-020-01065-z
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发表时间：
2021-01-12
影响因子：
1.8
通讯作者：
Kanai, Hiroshi
中科院分区：
文献类型：
--
作者：
Nagasawa, Kanta;Fukase, Akiyo;Kanai, Hiroshi
目的红细胞聚集性是决定血液粘度的主要因素之一，是评价血液性质的重要指标。作为一种无创的定量诊断血液性质的方法，我们的研究小组通过将来自血管腔的散射功率谱与理论散射特性拟合来估计RBC聚集体的大小，以评估RBC聚集的程度。然而，有人认为，无论是否红细胞聚集或不，这会导致系统误差估计size.Methods的大小估计精度，我们计算和校正的衰减的血管腔中的红细胞聚集和非聚集的血管腔中的传播衰减是相同的。在血管腔中的衰减计算从两个不同depth.Results的光谱获得的基本实验中，使用微粒的情况下，随着浓度的增加，在传统的方法的估计精度下降，但估计的大小往往接近真实的大小，而不管浓度，消除传播衰减分量与所提出的方法。在人体手背静脉的体内实验中，大小估计为较大的红细胞聚集和较小的非aggregation.Conclusion这些结果表明，该方法可以提供精确的大小估计，考虑传播衰减分量，而不管血液条件的差异，如红细胞浓度和聚集程度。
Purpose Red blood cell (RBC) aggregation is one of the main factors that determines blood viscosity and an important indicator for evaluating blood properties. As a noninvasive and quantitative method for diagnosing blood properties, our research group estimated the size of RBC aggregates by fitting the scattered power spectrum from the blood vessel lumen with the theoretical scattering characteristics to evaluate the degree of RBC aggregation. However, it was assumed that the propagation attenuation of ultrasound in the vascular lumen was the same regardless of whether RBCs were aggregated or not, which caused systematic errors in the estimated size.Methods To improve the size estimation accuracy, we calculated and corrected the attenuation of the blood vessel lumen during RBC aggregation and non-aggregation. The attenuation in the blood vessel lumen was calculated with the spectra acquired from two different depths.Results In the basic experiments using microparticles, the estimation accuracy decreased as the concentration increased in the case of the conventional method, but the estimated size tended to approach the true size irrespective of the concentration, removing the propagation attenuation component with the proposed method. In the in vivo experiment on the human hand dorsal vein, the size was estimated to be larger during RBC aggregation and smaller during non-aggregation using the proposed method.Conclusion These results suggest that the proposed method can provide precise size estimation by considering the propagation attenuation component regardless of differences in blood conditions such as RBC concentration and degree of aggregation.