Amino acids as regulators of gene expression: molecular mechanisms
Amino acids as regulators of gene expression: molecular mechanisms
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DOI：
10.1016/j.bbrc.2003.07.020
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发表时间：
2004-01-09
影响因子：
3.1
通讯作者：
Fafournoux, P
中科院分区：
文献类型：
--
作者：
Jousse, C;Averous, J;Fafournoux, P
营养物质对哺乳动物基因表达的调控是哺乳动物根据饮食中营养物质的供给来调节其生理功能的重要机制。最近的研究表明，氨基酸能够自行调节许多基因的表达。这篇综述将描述AA饥饿后CHOP、天冬酰胺合成酶和IGFBP-1的调控，并特别关注其中的分子机制。(C) 2003 Elsevier Inc.版权所有。
Regulation of gene expression by nutrients in mammals is an important mechanism allowing them to adapt their physiological functions according to the supply of nutrient in the diet. It has been shown recently that amino acids are able to regulate by themselves the expression of numerous genes. CHOP, asparagine synthetase, and IGFBP-1 regulation following AA starvation will be described in this review with special interest in the molecular mechanisms involved. (C) 2003 Elsevier Inc. All rights reserved.