IMMUNOREGULATORY FEEDBACK BETWEEN INTERLEUKIN-1 AND GLUCOCORTICOID HORMONES
IMMUNOREGULATORY FEEDBACK BETWEEN INTERLEUKIN-1 AND GLUCOCORTICOID HORMONES
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DOI：
10.1126/science.3014662
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发表时间：
1986-08-08
期刊：
影响因子：
56.9
通讯作者：
DINARELLO, CA
中科院分区：
文献类型：
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作者：
BESEDOVSKY, H;DELREY, A;DINARELLO, CA
免疫调节细胞因子，包括白细胞介素-1（IL-1）的产生和作用，在体内和体外受到糖皮质激素的抑制。相反，暴露于纽卡斯尔病病毒制剂的人白细胞释放的因子增加了葡萄糖皮质激素的血液水平。这种活性被IL-1的抗体中和。因此，测试了IL-1刺激垂体-肾上腺轴的能力。给予小鼠和大鼠亚致热原剂量的均质人单核细胞来源的IL-1或pI 7形式的人重组IL-1，可增加促肾上腺皮质激素（ACTH）和糖皮质激素的血液水平。另一种单核因子，肿瘤坏死因子，以及淋巴因子IL-2和γ当以等于或高于IL-1的剂量给药时，干扰素没有这种作用。IL-1对垂体-肾上腺轴的刺激作用似乎不是由成熟T淋巴细胞的次级释放产物介导的，因为IL-1注射到无胸腺裸鼠时具有内分泌活性。这些结果有力地支持了免疫调节反馈回路的存在，其中IL-1作为传入和糖皮质激素作为传入激素信号。
The production and action of immunoregulatory cytokines, including interleukin-1 (IL-1), are inhibited by glucocorticoid hormones in vivo and in vitro Conversely, glucocortoid blood levels were increased by factors released by human leukocytes exposed to Newcastle disease virus preparations. This activity was neutralized by an antibody to IL-1. Therefore the capacity of IL-1 to stimulate the pituitary-adrenal axis was tested. Administration of subpyrogenic doses of homogeneous human monocyte-derived IL-1 or the pI 7 form of human recombinant IL-1 to mice and rats increased blood levels of adrenocrticotropic hormone (ACTH) and glucocorticoids. Another monokine, tumor necrosis factor, and the lymphokines IL-2 and .gamma.-interferon had no such effects when administered in doses equivalent to or higher than those of IL-1. The stimulatory effect of IL-1 on the pituitary-adrenal axis seemed not be mediated by the secondary release of products from mature T lymphocytes since IL-1 was endocrinologically active when injected into athymic nude mice. These results strongly support the existence of an immunoregulatory feedback circuit in which IL-1 acts as an afferent and glucocorticoid as an afferent hormonal signal.