Long non-coding RNAs drive metastatic progression in melanoma (Review)
Long non-coding RNAs drive metastatic progression in melanoma (Review)
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DOI：
10.3892/ijo.2014.2691
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发表时间：
2014-12-01
影响因子：
5.2
通讯作者：
Boyne, James R.
中科院分区：
文献类型：
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作者：
Akhbari, Pouria;Whitehouse, Adrian;Boyne, James R.
转移性黑色素瘤是皮肤癌相关死亡的主要原因，虽然近年来靶向治疗取得了一些进展，但对新型治疗方法和可靠的诊断、预后和预测生物标志物的迫切需求仍然未得到满足。新一代测序 (NGS) 的出现让人们越来越认识到非编码基因组转录本在调节基因表达以及通过扩展影响疾病进展方面所发挥的作用。长非编码 RNA (IncRNA) 代表了这些新调控分子中最神秘的一个。我们对 IncRNA 如何调节生物学功能及其对疾病病因学重要性的了解虽然仍然有限，但正在迅速提高，特别是在它们在癌症中的作用方面。在此，我们回顾了几种对黑色素瘤疾病进展有影响的 IncRNA 的鉴定，并讨论了这些分子如何在分子水平上发挥作用。
Metastatic melanoma is the leading cause of skin-cancer related deaths and while in recent years some progress has been made with targeted therapies, there remains an urgent unmet need for novel therapeutic treatments and reliable diagnostic, prognostic and predictive biomarkers. The emergence of next generation sequencing (NGS) has seen a growing appreciation for the role played by non-coding genomic transcripts in regulating gene expression and by extension impacting on disease progression. The long non-coding RNAs (IncRNAs) represent the most enigmatic of these new regulatory molecules. Our understanding of how IncRNAs regulate biological functions and their importance to disease aetiology, while still limited, is rapidly improving, in particular with regards to their role in cancer. Herein we review the identification of several IncRNAs shown to impact on melanoma disease progression and discuss how these molecules are operating at the molecular level.