Differentiation of clinically benign and malignant breast lesions using diffusion-weighted imaging
Differentiation of clinically benign and malignant breast lesions using diffusion-weighted imaging
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DOI：
10.1002/jmri.10140
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发表时间：
2002-08-01
影响因子：
4.4
通讯作者：
Gao, JH
中科院分区：
文献类型：
--
作者：
Guo, Y;Cai, YQ;Gao, JH
目的：评价扩散加权成像（DWI）在区分乳腺良恶性病变中的价值。材料与方法：52例经病理证实的乳腺病变的女性受试者（平均年龄58岁，年龄范围= 25-75岁）进行了乳腺DWI，采用单次激发回波平面成像（EPI）序列，使用大B值。结果：乳腺良性病变（1.57 ± 0.23）× 10（-3）mm（2）/s）和乳腺恶性病变（0.97 ± 0.20）× 10（-3）mm（2）/s）的ADC值差异很大。乳腺病变ADC值与肿瘤细胞数呈显著正相关（P < 0.01，r = -0.542）。结论：ADC值可作为乳腺良恶性病变鉴别诊断的有效指标。此外，肿瘤细胞结构对在良性和恶性乳腺肿瘤中获得的ADC具有显著影响。
Purpose: To evaluate the value of diffusion-weighted imaging (DWI) in distinguishing between benign and malignant breast lesions.Materials and Methods: Fifty-two female subjects (mean age 58 years, age range = 25-75 years) with histopathologically proven breast lesions underwent DWI of the breasts, with a single-shot echo-planar imaging (EPI) sequence using large b values. The computed mean apparent diffusion coefficients (ADCs) of the breast lesions and cell density were then correlated.Results: The ADCs varied substantially between benign breast lesions ((1.57 +/- 0.23) x 10(-3) mm(2)/second) and malignant breast lesions ((0.97 +/- 0.20) x 10(-3) mm(2)/second). In addition, the mean ADCs of the breast lesions correlated well with tumor cellularity (P < 0.01, r = -0.542).Conclusion: The ADC would be an effective parameter in distinguishing between malignant and benign breast lesions. Further, tumor cellularity has a significant influence on the ADCs obtained in both benign and malignant breast tumors.