Cranial volume, mild cognitive deficits, and functional limitations associated with diabetes in a community sample.
Cranial volume, mild cognitive deficits, and functional limitations associated with diabetes in a community sample.
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DOI：
10.1093/arclin/acp091
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发表时间：
2010-02
期刊：
影响因子：
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通讯作者：
Andrea L. Christman;T. Vannorsdall;G. Pearlson;F. Hill-Briggs;D. Schretlen
中科院分区：
文献类型：
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作者：
Andrea L. Christman;T. Vannorsdall;G. Pearlson;F. Hill-Briggs;D. Schretlen
糖尿病与老年人痴呆有关，但目前尚不清楚非痴呆型2型糖尿病成年人是否在认知、神经解剖学和日常功能方面表现出细微的异常。利用301名社区居民、中老年人的衰老、脑成像和认知研究样本，我们对28名糖尿病患者和150名非糖尿病患者进行了二次分析。我们分析了脑磁共振成像数据、认知测试表现和日常生活中个人和工具活动的评分（PADL/IADL）。与对照组相比，糖尿病患者的脑-颅内容积比较低（69.3 +/- 4.5% vs. 71.7 +/- 4.6%; p < 0.02），在工作记忆、处理速度、流畅性和结晶智力方面表现较差（均p < 0.05）。工作记忆和处理速度的下降与IADL限制有关（p < 0.01）。无痴呆的成人糖尿病患者表现出神经解剖和认知异常。他们的认知缺陷与日常功能限制有关。
Diabetes is associated with dementia in older adults, but it remains unclear whether nondemented adults with type 2 diabetes show subtle abnormalities across cognition, neuroanatomy, and everyday functioning. Using the Aging, Brain Imaging, and Cognition study sample of 301 community-dwelling, middle-aged and older adults, we conducted a secondary analysis on 28 participants with and 150 participants without diabetes. We analyzed brain magnetic resonance imaging data, cognitive test performance, and informant ratings of personal and instrumental activities of daily living (PADL/IADL). Relative to controls, participants with diabetes had lower brain-to-intracranial volume ratios (69.3 +/- 4.5% vs. 71.7 +/- 4.6%; p < .02), and performed more poorly on measures of working memory, processing speed, fluency, and crystallized intelligence (all p <.05). Decrements in working memory and processing speed were associated with IADL limitations (p < .01). Nondemented adults with diabetes exhibit neuroanatomic and cognitive abnormalities. Their cognitive deficits correlate with everyday functional limitations.