Upregulation of renal endothelin receptors in rats with cyclosporine A-induced nephrotoxicity.
Upregulation of renal endothelin receptors in rats with cyclosporine A-induced nephrotoxicity.
复制标题
环孢素 A 诱导的肾毒性大鼠肾内皮素受体的上调。
DOI：
10.1016/0014-2999(90)90346-8
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发表时间：
1990
影响因子：
5
通讯作者：
D. Brooks
中科院分区：
文献类型：
--
作者：
P. Nambi;M. Pullen;L. Contino;D. Brooks
用结合分析法检测环孢素A(CyA)处理的大鼠的内皮素受体。环孢素A 50 mg/kg ip。连续服药4天后肾功能受损，表现为血肌酐浓度显著升高(从0.46±0.02 mg/dl升至0.61±0.03 mg/dl，P<；0.01)，24 h肌酐清除率显著下降(从0.65±0.04 ml/min降至0.41±0.02ml/min/100g，P<；0.01)。经CyA处理的大鼠肾脏内皮素(ET)受体密度显著增加(312±34比196±26 fmol/mg蛋白，P<；0.01)。这些数据支持内皮素可能参与了与环磷酰胺引起的肾毒性相关的肾血管阻力增加。
Measurement of endothelin receptors by binding assay was performed in rats treated with cyclosporine A (CYA). Cyclosporine A administration at 50 mg/kg i.p. for 4 days resulted in renal function impairment as indicated by a significant increase in serum creatinine concentration (from 0.46 ± 0.02 to 0.61 ± 0.03 mg/dl, P < 0.01) and a significant decrease in 24 h creatinine clearance (from 0.65 ± 0.04 to 0.41 ± 0.02 ml/min per 100 g, P < 0.01). Renal endothelin (ET) receptor density was significantly higher in CYA-treated rats (312 ± 34 vs. 196 ± 26 fmol/mg protein, P < 0.01). These data support the possible involvement for endothelin in the increased renal vascular resistance associated with CYA-induced nephrotoxicity.