Regulation of tissue factor gene expression in monocytes and endothelial cells: Thromboxane A2 as a new player.
Regulation of tissue factor gene expression in monocytes and endothelial cells: Thromboxane A2 as a new player.
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DOI：
10.1016/j.vph.2014.05.005
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发表时间：
2014-08
影响因子：
4
通讯作者：
Mackman, Nigel
中科院分区：
文献类型：
--
作者：
Bode, Michael;Mackman, Nigel
组织因子（TF）是凝血级联的主要激活因子。在正常情况下，内皮细胞（ECs）和血细胞（如单核细胞）不表达TF。然而，细菌脂多糖（LPS）在单核细胞中诱导TF表达，导致内毒素血症和败血症期间弥散性血管内凝血。在体外，多种刺激可诱导内皮细胞中的TF表达，但目前尚不清楚内皮细胞在体内表达多少TF。LPS诱导单核细胞和内皮细胞中TF基因表达是通过多种细胞内信号通路和转录因子NF-κB、AP-1和Egr-1介导的。相反，血管内皮细胞生长因子（VEGF）通过转录因子NFAT和Egr-1诱导TF基因在ECs中的表达。同样，氧化磷脂（oxPAPC）通过NFAT和Egr-1在ECs和可能的单核细胞中诱导TF表达。血栓素（TX） A2现在可以添加到诱导单核细胞和内皮细胞中TF基因表达的刺激列表中。有趣的是，在肿瘤坏死因子(TNF)-α刺激的ECs和LPS刺激的单核细胞中，抑制tx -前列腺素（TP）受体也会降低TF的表达，这表明TP受体拮抗剂可能有助于降低脉管系统中病理性TF的表达。
Tissue factor (TF) is the primary activator of the coagulation cascade. Under normal conditions, endothelial cells (ECs) and blood cells, such as monocytes, do not express TF. However, bacterial lipopolysaccharide (LPS) induces TF expression in monocytes and this leads to disseminated intravascular coagulation during endotoxemia and sepsis. A variety of stimuli induce TF expression in ECs in vitro, although it is unclear how much TF is expressed by the endothelium in vivo. LPS induction of TF gene expression in monocytic cells and ECs is mediated by various intracellular signaling pathways and the transcription factors NF-κB, AP-1 and Egr-1. In contrast, vascular endothelial cell growth factor (VEGF) induces TF gene expression in ECs via the transcription factors NFAT and Egr-1. Similarly, oxidized phospholipids (oxPAPC) induce TF expression in ECs and possibly monocytes via NFAT and Egr-1. Thromboxane (TX) A2 can now be added to the list of stimuli that induce TF gene expression in both monocytes and ECs. Interestingly, inhibition of the TX-prostanoid (TP) receptor also reduces TF expression in ECs stimulated with tumor necrosis factor (TNF)-α and monocytes stimulated with LPS, which suggests that TP receptor antagonist may be useful in reducing pathologic TF expression in the vasculature.
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影响因子：
3.1
作者：
Erlich, J;Fearns, C;Mackman, N
通讯作者：
Mackman, N
影响因子：
20.3
作者：
Guha, M;O'Connell, MA;Mackman, N
通讯作者：
Mackman, N
影响因子：
2.2
作者：
Chu, AJ;Wang, ZG;Seto, A
通讯作者：
Seto, A
影响因子：
4
作者：
Del Turco, Serena;Basta, Giuseppina;De Caterina, Raffaele
通讯作者：
De Caterina, Raffaele
影响因子：
64.8
作者：
GLOVER, JNM;HARRISON, SC
通讯作者：
HARRISON, SC