Know Thyself: RIG-I-Like Receptor Sensing of DNA Virus Infection
Know Thyself: RIG-I-Like Receptor Sensing of DNA Virus Infection
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DOI：
10.1128/jvi.01085-19
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发表时间：
2019-09
影响因子：
5.4
通讯作者：
Yang Zhao;John Karijolich
中科院分区：
文献类型：
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作者：
Yang Zhao;John Karijolich
RIG-I样受体（RLR）是双链RNA结合蛋白，其通过识别通常不存在于宿主转录组中的RNA特征而在启动和调节细胞固有免疫中起作用。虽然它们最初是在RNA病毒感染的背景下表征的，但现在已经积累了证据来确定RLRs在DNA病毒感染中的作用。RIG-I样受体（RLR）是一种双链RNA结合蛋白，通过识别宿主转录组中通常不存在的RNA特征，在启动和调节细胞固有免疫中发挥作用。虽然它们最初是在RNA病毒感染的背景下表征的，但现在已经积累了证据来确定RLRs在DNA病毒感染中的作用。在这里，我们回顾了最近的进展，在RLR介导的限制DNA病毒感染的RLR配体感测的重点。
The RIG-I-like receptors (RLRs) are double-stranded RNA-binding proteins that play a role in initiating and modulating cell intrinsic immunity through the recognition of RNA features typically absent from the host transcriptome. While they are initially characterized in the context of RNA virus infection, evidence has now accumulated establishing the role of RLRs in DNA virus infection. ABSTRACT The RIG-I-like receptors (RLRs) are double-stranded RNA-binding proteins that play a role in initiating and modulating cell intrinsic immunity through the recognition of RNA features typically absent from the host transcriptome. While they are initially characterized in the context of RNA virus infection, evidence has now accumulated establishing the role of RLRs in DNA virus infection. Here, we review recent advances in the RLR-mediated restriction of DNA virus infection with an emphasis on the RLR ligands sensed.