Serum resistin is associated with the severity of microangiopathies in type 2 diabetes
Serum resistin is associated with the severity of microangiopathies in type 2 diabetes
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DOI：
10.1016/j.bbrc.2007.01.144
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发表时间：
2007-04-06
影响因子：
3.1
通讯作者：
Makino, Hideichi
中科院分区：
文献类型：
--
作者：
Osawa, Haruhiko;Ochi, Masaaki;Makino, Hideichi
抵抗素，由脂肪细胞分泌，在啮齿类动物中引起胰岛素抵抗和糖尿病。为了确定血清抵抗素与人类糖尿病微血管病变之间的关系，我们分析了238名日本T2DM受试者。在晚期视网膜病变（增生前或增生前）（P = 0.0130）、晚期肾病（III期或IV期）（P = 0.0151）或神经病变（P = 0.0013）的受试者中，平均血清抵抗素水平较高。简单回归分析显示，血清抵抗素与视网膜病变分期（P = 0.0212）、肾病分期（P = 0.0052）、神经病变分期（P = 0.0013）呈正相关。经年龄、性别和BMI校正后的多元回归分析显示，血清抵抗素与视网膜病变分期（P = 0.0144）、肾病分期（P = 0.0111）和神经病变（P = 0.0053）相关。血清抵抗素与晚期微血管病变数量呈正相关，与年龄、性别、BMI、T2DM病程（P = 0.0318）或血清肌酐（P = 0.0092）无关。因此，血清抵抗素水平与T2DM微血管病变严重程度呈正相关。(c) 2007爱思唯尔公司版权所有。
Resistin, secreted from adipocytes, causes insulin resistance and diabetes in rodents. To determine the relation between serum resistin and diabetic microangiopathies in humans, we analyzed 238 Japanese T2DM subjects. Mean serum resistin was higher in subjects with either advanced retinopathy (preproliferative or proliferative) (P = 0.0130), advanced nephropathy (stage III or IV) (P = 0.0151), or neuropathy (P = 0.0013). Simple regression analysis showed that serum resistin was positively correlated with retinopathy stage (P = 0.0212), nephropathy stage (P = 0.0052), and neuropathy (P = 0.0013). Multiple regression analysis adjusted for age, gender, and BMI, revealed that serum resistin was correlated with retinopathy stage (P = 0.0144), nephropathy stage (P = 0.0111), and neuropathy (P = 0.0053). Serum resistin was positively correlated with the number of advanced microangiopathies, independent of age, gender, BMI, and either the duration of T2DM (P = 0.0318) or serum creatinine (P = 0.0092). Therefore, serum resistin was positively correlated with the severity of microangiopathies in T2DM. (c) 2007 Elsevier Inc. All rights reserved.