How to measure the transmetallation of a gadolinium complex
How to measure the transmetallation of a gadolinium complex
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DOI：
10.1002/cmmi.388
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发表时间：
2010-11-01
影响因子：
--
通讯作者：
Muller, R. N.
中科院分区：
文献类型：
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作者：
Laurent, S.;Vander Elst, L.;Muller, R. N.
顺磁性络合物作为造影剂的适宜性不仅取决于它们的弛豫度，还取决于它们对内源离子跨金属迁移过程的稳定性和惰性。在这项工作中，我们描述了一种通过37℃下水质子顺磁纵向弛豫速率的演化来研究顺磁Gd络合物稳定性的简便方法。版权所有(C)2010 John Wiley&Sons，Ltd.
The suitability of paramagnetic complexes as contrast agents depends not only on their relaxivity but also on their stability and inertness towards transmetallation processes by endogenous ions. In this work, we describe a convenient method to study the stability of paramagnetic Gd complexes through the evolution of the paramagnetic longitudinal relaxation rate of water protons at 37 degrees C. Copyright (C) 2010 John Wiley & Sons, Ltd.