Fabrication of novel biodegradable porous bone scaffolds based on amphiphilic hydroxyapatite nanorods.
Fabrication of novel biodegradable porous bone scaffolds based on amphiphilic hydroxyapatite nanorods.
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DOI：
10.1016/j.msec.2017.02.103
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发表时间：
2017-06
期刊：
影响因子：
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通讯作者：
Xiaoyan Zheng;Junfeng Hui;Hui Li;Chenhui Zhu;Xiufu Hua;Haixia Ma;Daidi Fan
中科院分区：
文献类型：
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作者：
Xiaoyan Zheng;Junfeng Hui;Hui Li;Chenhui Zhu;Xiufu Hua;Haixia Ma;Daidi Fan
本文介绍了一种新型两亲性羟基磷灰石（HAp）纳米棒的合成方法及其生物学应用。所制备的HAp纳米棒能够分散在水、乙醇和环己烷中。PEG 20000和疏水性油酸（OA）的多齿配体在棒状物表面的共锚定赋予了它们优异的两栖性能。以具有良好生物相容性的两亲性HAp纳米棒为无机相，类人胶原蛋白（HLC）为有机相，京尼平为交联剂，制备了HLC/HAp多孔支架（HLC：HAp = 1：4，w/w）。孔径为150 ~ 200 μm的支架的压缩应力和三点弯曲强度分别达到3.4 MPa和5.4 MPa左右，孔隙率为77.35 ± 3.75%。细胞学实验表明，HLC/HAp支架能促进细胞增殖和分化。结果表明，这些新型的两亲性HAp纳米棒可以预期成为公认的用于骨修复和相关应用的多孔支架的优良无机材料。
This paper describes a new synthetic strategy and biological application for novel amphiphilic hydroxyapatite (HAp) nanorods. The prepared HAp nanorods were able to be dispersed in water, ethyl alcohol and cyclohexane. The co-anchoring of the multidentate ligands of PEG 20000 and hydrophobic oleic acid (OA) on the rods' surfaces endowed them with excellent amphibious properties. Utilizing amphiphilic HAp nanorods with excellent biocompatibility as the inorganic phase, human-like collagen (HLC) as the organic phase and natural genipin as the cross-linker, optimal HLC/HAp porous scaffolds (HLC: HAp = 1:4, w/w) were fabricated. The compression stress and three-point bending strength of the scaffolds with pore diameters of 150 to 200 μm reached approximately 3.4 MPa and 5.4 MPa, respectively, and their porosity was 77.35 ± 3.75%. Cytological tests showed that HLC/HAp scaffolds could contribute to cell proliferation and differentiation. The results indicated that these novel amphiphilic HAp nanorods can be expected to become recognized as an excellent inorganic material for the porous scaffolds used in repairing bone and related applications.