A dynamic sequence of visual processing initiated by gaze shifts.
A dynamic sequence of visual processing initiated by gaze shifts.
复制标题
由目光转移引发的视觉处理的动态序列。
DOI：
10.1038/s41593-023-01481-7
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发表时间：
2023
影响因子：
25
通讯作者：
Niell,CristopherM
中科院分区：
文献类型：
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作者：
Parker,PhilipRL;Martins,DylanM;Leonard,EmmalynSP;Casey,NathanM;Sharp,ShelbyL;Abe,ElliottTT;Smear,MatthewC;Yates,JacobL;Mitchell,JudeF;Niell,CristopherM
动物在探索视觉场景时会移动头部和眼睛。这些运动的神经相关性已在啮齿动物初级视觉皮层（V1）中发现，但其来源和计算作用尚不清楚。我们通过将头部和眼睛运动测量与自由运动小鼠的神经记录相结合来解决这一问题。V1神经元主要对凝视转移做出反应，其中头部运动伴随着扫视眼球运动，而不是对补偿眼球运动稳定凝视的头部运动做出反应。各种各样的活动模式跟随着目光的转移，这些活动一起形成了一个在黑暗中不存在的时间序列。目光转移反应类似于那些诱发的连续闪光刺激，这表明一个大的组成部分对应于新的视觉输入的发病。值得注意的是，神经元的反应顺序与它们的空间频率偏差相匹配，与粗到细的处理一致。记录在自由凝视的绒猴揭示了一个类似的序列后扫视，也对齐空间频率偏好。我们的研究结果表明，在小鼠和绒猴的主动视觉包括一个动态的时间序列的神经活动与视觉采样。
Animals move their head and eyes as they explore the visual scene. Neural correlates of these movements have been found in rodent primary visual cortex (V1), but their sources and computational roles are unclear. We addressed this by combining head and eye movement measurements with neural recordings in freely moving mice. V1 neurons responded primarily to gaze shifts, where head movements are accompanied by saccadic eye movements, rather than to head movements where compensatory eye movements stabilize gaze. A variety of activity patterns followed gaze shifts and together these formed a temporal sequence that was absent in darkness. Gaze-shift responses resembled those evoked by sequentially flashed stimuli, suggesting a large component corresponds to onset of new visual input. Notably, neurons responded in a sequence that matches their spatial frequency bias, consistent with coarse-to-fine processing. Recordings in freely gazing marmosets revealed a similar sequence following saccades, also aligned to spatial frequency preference. Our results demonstrate that active vision in both mice and marmosets consists of a dynamic temporal sequence of neural activity associated with visual sampling.