High sensitivity of the human circadian melatonin rhythm to resetting by short wavelength light
High sensitivity of the human circadian melatonin rhythm to resetting by short wavelength light
复制标题
DOI：
10.1210/jc.2003-030570
复制
发表时间：
2003-09-01
影响因子：
5.8
通讯作者：
Czeisler, CA
中科院分区：
文献类型：
--
作者：
Lockley, SW;Brainard, GC;Czeisler, CA
哺乳动物中的内源性昼夜节律振荡器位于视交叉上核，从专门的感光视网膜神经节细胞亚群接收环境光输入。人类的昼夜节律起搏器对眼睛的光线照射非常敏感，即使对于一些完全失明的人也是如此。对白光的重置反应的强度取决于曝光的时间、强度、持续时间、数量和模式。我们在此报告，通过松果体褪黑激素节律测量的人类昼夜节律重置反应也与波长相关。暴露于 460 nm 单色光 6.5 小时，比同等光子密度的 555 nm 单色光 6.5 小时暴露两倍的昼夜节律相位延迟。同样，与 555 nm 单色光相比，460 nm 单色光造成的褪黑激素抑制量是 555 nm 单色光的两倍，并且除了波长之外还取决于曝光时间。这些研究表明，人类昼夜节律起搏器对光的敏感度峰值相对于三锥视觉明视系统发生了蓝移，其敏感度峰值约为555 nm。因此，在量化重置人类昼夜节律起搏器所需的光驱动时，照度的标准单位明视勒克斯是不合适的。
The endogenous circadian oscillator in mammals, situated in the suprachiasmatic nuclei, receives environmental photic input from specialized subsets of photoreceptive retinal ganglion cells. The human circadian pacemaker is exquisitely sensitive to ocular light exposure, even in some people who are otherwise totally blind. The magnitude of the resetting response to white light depends on the timing, intensity, duration, number and pattern of exposures. We report here that the circadian resetting response in humans, as measured by the pineal melatonin rhythm, is also wavelength dependent. Exposure to 6.5 h of monochromatic light at 460 nm induces a two-fold greater circadian phase delay than 6.5 h of 555 nm monochromatic light of equal photon density. Similarly, 460 nm monochromatic light causes twice the amount of melatonin suppression compared to 555 nm monochromatic light, and is dependent on the duration of exposure in addition to wavelength. These studies demonstrate that the peak of sensitivity of the human circadian pacemaker to light is blue-shifted relative to the three-cone visual photopic system, the sensitivity of which peaks at similar to555 nm. Thus photopic lux, the standard unit of illuminance, is inappropriate when quantifying the photic drive required to reset the human circadian pacemaker.