Cancer regression and autoimmunity in patients after clonal repopulation with antitumor lymphocytes
Cancer regression and autoimmunity in patients after clonal repopulation with antitumor lymphocytes
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DOI：
10.1126/science.1076514
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发表时间：
2002-10-25
期刊：
影响因子：
56.9
通讯作者：
Rosenberg, SA
中科院分区：
文献类型：
--
作者：
Dudley, ME;Wunderlich, JR;Rosenberg, SA
我们在这里报道了在非清髓性预处理方案后，针对过度表达的自体分化抗原的高度选择性的肿瘤反应性 T 细胞的过继转移，转移给转移性黑色素瘤患者。这种方法导致这些癌症患者体内 T 细胞持续克隆再增殖，转移的细胞在体内增殖，表现出功能活性，并运输到肿瘤部位。这导致患者转移性黑色素瘤消退以及自身免疫性黑色素细胞破坏的发生。这种方法为治疗癌症患者以及人类免疫缺陷病毒相关的获得性免疫缺陷综合症和其他传染病患者提供了新的可能性。
We report here the adoptive transfer, to patients with metastatic melanoma, of highly selected tumor-reactive T cells directed against overexpressed self-derived differentiation antigens after a nonmyeloablative conditioning regimen. This approach resulted in the persistent clonal repopulation of T cells in those cancer patients, with the transferred cells proliferating in vivo, displaying functional activity, and trafficking to tumor sites. This led to regression of the patients metastatic melanoma as well as to the onset of autoimmune melanocyte destruction. This approach presents new possibilities for the treatment of patients with cancer as well as patients with human immunodeficiency virus related acquired immunodeficiency syndrome and other infectious diseases.