Multivariate Neural Representations of Value during Reward Anticipation and Consummation in the Human Orbitofrontal Cortex.
Multivariate Neural Representations of Value during Reward Anticipation and Consummation in the Human Orbitofrontal Cortex.
复制标题
人类眶额皮层奖励预期和完成过程中价值的多元神经表征
DOI：
10.1038/srep29079
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发表时间：
2016-07-05
影响因子：
4.6
通讯作者：
Chan RC
中科院分区：
文献类型：
--
作者：
Yan C;Su L;Wang Y;Xu T;Yin DZ;Fan MX;Deng CP;Hu Y;Wang ZX;Cheung EF;Lim KO;Chan RC
眶额皮质（OFC）在价值加工中的作用是目前研究的热点。使用平滑和平均的传统成像分析在研究OFC时可能不够敏感，因为OFC具有异质的解剖结构和功能。在本研究中，我们采用表征相似性分析（RSA）揭示了在预期和完成阶段与价值处理相关的OFC的多体素fMRI模式。我们发现，在奖励完成过程中，OFC的多体素激活模式编码的是量级和部分价信息（赢与输），而不是结果（有利与不利）。此外，外侧OFC而不是内侧OFC编码丢失信息。此外，我们发现OFC编码值的方式与奖励预期时腹侧纹状体（VS）或前脑岛（AI）的编码方式相似，与奖励完成时内侧前额叶皮层（MPFC）和VS的编码方式相似。相比之下，单变量分析没有显示OFC激活的变化。这些发现表明OFC在奖励预期和完成过程中的价值加工中起着重要作用。
The role of the orbitofrontal cortex (OFC) in value processing is a focus of research. Conventional imaging analysis, where smoothing and averaging are employed, may not be sufficiently sensitive in studying the OFC, which has heterogeneous anatomical structures and functions. In this study, we employed representational similarity analysis (RSA) to reveal the multi-voxel fMRI patterns in the OFC associated with value processing during the anticipatory and the consummatory phases. We found that multi-voxel activation patterns in the OFC encoded magnitude and partial valence information (win vs. loss) but not outcome (favourable vs. unfavourable) during reward consummation. Furthermore, the lateral OFC rather than the medial OFC encoded loss information. Also, we found that OFC encoded values in a similar way to the ventral striatum (VS) or the anterior insula (AI) during reward anticipation regardless of motivated response and to the medial prefrontal cortex (MPFC) and the VS in reward consummation. In contrast, univariate analysis did not show changes of activation in the OFC. These findings suggest an important role of the OFC in value processing during reward anticipation and consummation.