IMMUNOGENICITY OF BOILED COMPARED WITH FORMALIZED LEPTOSPIRAL VACCINES IN RABBITS, HAMSTERS AND HUMANS
IMMUNOGENICITY OF BOILED COMPARED WITH FORMALIZED LEPTOSPIRAL VACCINES IN RABBITS, HAMSTERS AND HUMANS
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DOI：
10.1017/s0022172400026450
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发表时间：
1980-01-01
影响因子：
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通讯作者：
FAINE, S
中科院分区：
文献类型：
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作者：
ADLER, B;FAINE, S
钩端螺旋体（波摩那型钩端螺旋体）在化学成分确定的培养基中生长，如果用福尔马林杀死钩端螺旋体，而不是煮沸，则皮内给药时具有免疫原性。煮沸的钩端螺旋体对兔和仓鼠具有免疫原性，并保护仓鼠免受攻击感染。煮沸的双曲复合体钩端螺旋体（patoc血清型）在人体内确实保留了一些免疫原性，但抗血清不能保护仓鼠免受波摩那血清型的攻击。
Leptospires (Leptospira interrogans serovar pomona) grown in chemically defined medium were immunogenic when given intradermally in humans if the leptospires were killed with formalin but not if they were boiled. Boiled leptospires were immunogenic for rabbits and hamsters and protected hamsters from challenge infection. Boiled leptospires of the biflexa complex, serovar patoc, did retain some immunogenicity in humans, but the antisera did not protect hamsters against challenge with serovar pomona.