Hippocampal CA1 replay becomes less prominent but more rigid without inputs from medial entorhinal cortex
Hippocampal CA1 replay becomes less prominent but more rigid without inputs from medial entorhinal cortex
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DOI：
10.1038/s41467-019-09280-0
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发表时间：
2019-03-22
影响因子：
16.6
通讯作者：
Leibold, Christian
中科院分区：
文献类型：
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作者：
Chenani, Alireza;Sabariego, Marta;Leibold, Christian
海马体是学习和记忆的重要大脑区域。然而，网络机制的记忆存储，巩固和检索仍然没有完全理解。在θ振荡期间的位置单元序列被认为是在非θ状态期间重放，以支持整合和路线规划。在内侧内嗅皮层（MEC）病变的动物中，θ相关海马活动的时间组织被破坏，这使我们能够测试重放是否也受到损害。两种不同的分析-运行和休息时期之间的共激活模式的比较和分析的复发的位置细胞序列-揭示了增强重放的行为减少在MEC-病变与对照组大鼠。相反，内在网络结构的程度之前和之后的行为仍然不受MEC病变。因此，θ状态期间的MEC依赖的时间协调似乎有助于行为相关的可塑性，但不会破坏预先存在的功能连接。
The hippocampus is an essential brain area for learning and memory. However, the network mechanisms underlying memory storage, consolidation and retrieval remain incompletely understood. Place cell sequences during theta oscillations are thought to be replayed during non-theta states to support consolidation and route planning. In animals with medial entorhinal cortex (MEC) lesions, the temporal organization of theta-related hippocampal activity is disrupted, which allows us to test whether replay is also compromised. Two different analyses-comparison of co-activation patterns between running and rest epochs and analysis of the recurrence of place cell sequences-reveal that the enhancement of replay by behavior is reduced in MEC-lesioned versus control rats. In contrast, the degree of intrinsic network structure prior and subsequent to behavior remains unaffected by MEC lesions. The MEC-dependent temporal coordination during theta states therefore appears to facilitate behavior-related plasticity, but does not disrupt pre-existing functional connectivity.