A POINT-SOURCE OUTBREAK OF CAMPYLOBACTERIOSIS ASSOCIATED WITH CONSUMPTION OF RAW-MILK
A POINT-SOURCE OUTBREAK OF CAMPYLOBACTERIOSIS ASSOCIATED WITH CONSUMPTION OF RAW-MILK
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DOI：
10.1093/infdis/152.3.592
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发表时间：
1985-01-01
影响因子：
6.4
通讯作者：
ROBINSON, RA
中科院分区：
文献类型：
--
作者：
KORLATH, JA;OSTERHOLM, MT;ROBINSON, RA
经过一天的实地考察明尼苏达州[美国]农场，22（45%）的49名三年级学生和三（14%）的21名成人伴侣开发弯曲杆菌病。从13名儿童和1名无症状成人的标本中分离出空肠弯曲菌。疾病与野餐时饮用生牛奶（比值比= 41.0，P < 0.0001）和参与手工挤奶（比值比= 37.5，P < 0.0001）有关。另外两项发现涉及食用生奶作为传播媒介。第一，饮用生奶而不挤奶的人患病的比值比为11.8（P < 0.01），而挤奶而不饮用生奶的人患病的比值比仅为1.2（P > 0.02）。第二，患病率与饮用生奶量之间存在剂量反应关系（P < 0.0001）。无论是潜伏期的中位数还是疾病的持续时间都与消耗的牛奶量无关。所有粪便培养C阳性的人。空肠排泄有机体至少两周，但不到六周。没有记录到继发性病例。
After a one-day field trip to a Minnesota [USA] farm, 22 (45%) of 49 third-grade students and three (14%) of 21 adult chaperones developed campylobacteriosis. Campylobacter jejuni was isolated from specimens of 13 children and one asymptomatic adult. Illness was associated with the consumption of a raw milk during a picnic lunch (odds ratio = 41.0, P < 0.0001) and participation in hand milking of cows (odds ratio = 37.5, P < 0.0001). Two additional findings implicated consumption of raw milk as the vehicle for transmission. First, the odds ratio for illness among those who drank raw milk and did not milk cows was 11.8 (P < 0.01), whereas the odds ratio for illness among those who milked cows but did not drink raw milk was only 1.2 (P > 0.02). Second, there was a dose-response relation between the occurrence of illness and the quantity of raw milk consumed (P < 0.0001). Neither the median incubation period nor duration of illness was related to the amount of milk consumed. All persons with a stool culture positive for C. jejuni excreted the organism for at least two weeks, but less than six weeks. No secondary cases of illness were documented.