Current status of brain imaging in anxiety disorders
Current status of brain imaging in anxiety disorders
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DOI：
10.1097/yco.0b013e328319bd10
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发表时间：
2009-01-01
影响因子：
6.9
通讯作者：
Moussally, Joanna
中科院分区：
文献类型：
--
作者：
Damsa, Cristian;Kosel, Markus;Moussally, Joanna
综述目的本研究回顾了近年来有关焦虑症脑成像研究的文献。越来越多的证据表明，焦虑症的神经影像学有助于更好地了解这些疾病的神经生物学，通过识别焦虑症状之前或之后发生的大脑修饰。使用脑成像、焦虑症、创伤后应激障碍、强迫症、广泛性焦虑症、特定恐怖症、社交焦虑症、惊恐障碍和广场恐怖症等关键词在MEDLINE中对文献进行系统检索（1978年1月至2008年7月）。迭代检索所有试验中引用的参考文献，以识别缺失的研究。我们的审查只集中在去年的findings.Recent findingsThere is a consensus on the critical role of the amygdala，anterior cingulate cortex and anterior in the pathophysiology of anxiety disorders.SummaryBrain imaging research in anxiety disorders has become more important，especially in the last decade，because of the opportunity to validate neurobiological hypotheses for anxiety disorders.因此，神经影像学数据提出了焦虑症的神经生物学原因的问题，开辟了新的思考，不仅对药物治疗，而且对焦虑症的疾病分类。
Purpose of reviewThis study reviews the most recent literature about brain imaging research in anxiety disorders. There is a growing body of evidence that neuroimaging of anxiety disorders contributes to a better understanding of the neurobiology of these disorders, by identifying cerebral modifications occurring previously or subsequent to symptoms of anxiety. A systematic search of the literature (January 1 978-July 2008) was performed in MEDLINE using the keywords brain imaging, anxiety disorders, posttraumatic stress disorder, obsessive-compulsive disorder, generalized anxiety disorder, specific phobia, social anxiety disorder, panic disorders and agoraphobia. References cited in all trials were searched iteratively to identify missing studies. Our review focused only on the last year's findings.Recent findingsThere is a consensus on the crucial role of the amygdala, anterior cingulate cortex and insula in the pathophysiology of anxiety disorders.SummaryBrain imaging research in anxiety disorders has become increasingly important, especially in the last decade, because of the opportunity to validate neurobiological hypotheses for anxiety disorders. Thus, neuroimaging data raise the question of the neurobiological cause of anxiety disorders, opening up new reflections not only on pharmacological treatments but also on the nosology of the anxiety disorders.