2 CLASSES OF PDGF RECEPTOR RECOGNIZE DIFFERENT ISOFORMS OF PDGF
2 CLASSES OF PDGF RECEPTOR RECOGNIZE DIFFERENT ISOFORMS OF PDGF
复制标题
DOI：
10.1126/science.2836952
复制
发表时间：
1988-06-10
期刊：
影响因子：
56.9
通讯作者：
BOWENPOPE, DF
中科院分区：
文献类型：
--
作者：
HART, CE;FORSTROM, JW;BOWENPOPE, DF
先前涉及血小板衍生生长因子（PDGE）的研究基于这样的前提，即单个细胞表面受体结合PDGF的所有三种亚型（AA、BB和AB）。现在显示存在两种PDGF受体群体，并且可以通过其配体结合特异性来区分。B受体仅结合BB二聚体，而A/B受体结合AA、BB和AB二聚体。人皮肤成纤维细胞似乎表达的B受体是A/B受体的7倍。B受体负责大多数PDGF受体磷酸化。
Previous studies involving platelet-derived growth factor (PDGE) have been based on the premise that a single cell-surface receptor binds all three isoforms of PDGF (AA, BB and AB). It is now shown that two populations of PDGF receptor exist and can be distinguished by their ligand binding specificity. The B receptor binds only the BB dimer, whereas the A/B receptor binds AA, BB, and AB dimers. Human dermal fibroblasts appear to express seven times as much B receptors as A/B receptor. The B receptor is responsible for most PDGF receptor phosphorylation.