Recent Advances and Applications in N-Methylation of Amines and Imines
Recent Advances and Applications in N-Methylation of Amines and Imines
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DOI：
10.6023/cjoc201912031
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发表时间：
2020
影响因子：
1.9
通讯作者：
Feng Yan;Cai Shuang;Wu Wen;W. Wen;Li Bojie;W. Liansheng;Lei Zhu
中科院分区：
文献类型：
--
作者：
Feng Yan;Cai Shuang;Wu Wen;W. Wen;Li Bojie;W. Liansheng;Lei Zhu
N -Methylation of amines and imines is one of the most important reactions for C — N bond formation. It is widely utilized for both laboratary research and industrial applications. Traditional methylation reactions involve the use of flammable, explosive and toxic starting materials. In contrast, newly developed methods have overcome this point and provide a mild strategy. In this transformation, C1 carbon source for the methyl group is important which determines the type of catalyst, reaction conditions and substrate scope. Herein, the research progress for the N -methylation of amines and imines is summarized based on different C1 carbon source.
