LIPOLYSIS DURING FASTING - DECREASED SUPPRESSION BY INSULIN AND INCREASED STIMULATION BY EPINEPHRINE
LIPOLYSIS DURING FASTING - DECREASED SUPPRESSION BY INSULIN AND INCREASED STIMULATION BY EPINEPHRINE
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DOI：
10.1172/jci112785
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发表时间：
1987-01-01
影响因子：
15.9
通讯作者：
MILES, JM
中科院分区：
文献类型：
--
作者：
JENSEN, MD;HAYMOND, MW;MILES, JM
这些研究旨在确定禁食的胰岛素抵抗是否延伸到其抗脂解作用，以及禁食是否增强肾上腺素能刺激的脂解作用，而不依赖于血浆激素和底物浓度的变化。在正常志愿者禁食14小时（第1天）和84小时（第4天）后，在肾上腺素输注前和输注过程中用同位素（[1- 14 C]棕榈酸盐）测定棕榈酸盐通量。使用胰钳夹，7例受试者在两个研究日均达到恒定的血浆激素和葡萄糖浓度。6名受试者输注生理盐水并作为对照。在胰腺钳夹期间，尽管血浆胰岛素、胰高血糖素、生长激素、皮质醇、肾上腺素、去甲肾上腺素和葡萄糖浓度相似，但第4天的棕榈酸流量大于第1天（P < 0.01）。在两组受试者中，对肾上腺素的脂解反应在第4天比第1天更大（P < 0.05）。总之，禁食期间的脂解不完全被胰岛素抑制，更容易被肾上腺素刺激。
These studies were designed to determine whether the insulin resistance of fasting extends to its antilipolytic effects and whether fasting enhances the lipolytic effects of adrenergic stimulation independent of changes in plasma hormone and substrate concentrations. Palmitate flux was determined isotopically ([1-14C]palmitate) before and during epinephrine infusion in normal volunteers after a 14-h (day 1) and an 84-h (day 4) fast. Using a pancreatic clamp, constant plasma hormone and glucose concentrations were achieved on both study days in seven subjects. Six subjects were infused with saline and served as controls. During the pancreatic clamp, palmitate flux was greater (P < 0.01) on day 4 than day 1, despite similar plasma insulin, glucagon, growth hormone, cortisol, epinephrine, norepinephrine, and glucose concentrations. The lipolytic response to epinephrine was greater (P < 0.05) on day 4 than day 1 in both groups of subjects. In conclusion, lipolysis during fasting is less completely suppressed by insulin and more readily stimulated by epinephrine.