NEUTRALIZATION OF DIVERGENT HIV-1 ISOLATES BY CONFORMATION-DEPENDENT HUMAN-ANTIBODIES TO GP120
NEUTRALIZATION OF DIVERGENT HIV-1 ISOLATES BY CONFORMATION-DEPENDENT HUMAN-ANTIBODIES TO GP120
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DOI：
10.1126/science.1718036
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发表时间：
1991-10-04
期刊：
影响因子：
56.9
通讯作者：
HAIGWOOD, NL
中科院分区：
文献类型：
--
作者：
STEIMER, KS;SCANDELLA, CJ;HAIGWOOD, NL
被 HIV-1 感染者的抗体中和的 1 型人类免疫缺陷病毒 (HIV-1) 分离株谱比用纯化的 gp120 亚基免疫的动物血清中和的分离株谱更广。 这种更广泛的中和作用部分归因于保守 gp120 构象表位的抗体的存在。 纯化的构象依赖性 gp120 特异性人抗体比针对 gp120 中线性决定簇的人抗体中和了更广泛的病毒分离株，并且还负责 HIV-1 感染的人血清的大部分 gp120 特异性 CD4 阻断活性。 有效呈现这些构象依赖性中和表位的 gp120 亚单位疫苗应该比仅呈现线性决定簇的疫苗能够预防更广泛的 HIV-1 变体。
The spectrum of human immunodeficiency virus type 1 (HIV-1) isolates neutralized by antibodies from HIV-1-infected humans is broader than the spectrum of isolates neutralized by sera from animals immunized with purified gp120 subunits. This broader neutralization was due, in part, to the presence of antibodies to conserved gp120 conformational epitopes. Purified conformation-dependent gp120-specific human antibodies neutralized a wider range of virus isolates than human antibodies directed to linear determinants in gp120 and were also responsible for the majority of the gp120-specific CD4-blocking activity of HIV-1-infected human sera. A gp120 subunit vaccine that effectively presents these conformation-dependent neutralization epitopes should protect against a broader range of HIV-1 variants than a vaccine that presents exclusively linear determinants.